Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat

Biochemical and Biophysical Research Communications
Yoshitaka KubotaYasushi Saito

Abstract

The increased population of TLR2/TNF-alpha co-expressing adipocytes is associated with the development of insulin resistance. We have herein shown the significance of low-dose growth hormone (GH) supplementation for the regulation of TLR2 and TNF-alpha expressions in visceral fat using different kinds of mouse models fed with a high-fat diet. Low-dose GH supplementation reduced the increased population of TLR2/TNF-alpha co-expressing adipocytes in high-fat fed mice. The neutralization of IGF-1 abolished the effect of GH supplementation on the TLR2 expression using GH-overexpressing mice. IGF-1, but not GH, inhibited the FFA-induced TLR2 and TNF-alpha expression in 3T3-L1 cells. Finally, low-dose GH supplementation reduced the TLR2 expression without an obvious change in the visceral fat volume in ob/ob mice. These results indicate that low-dose GH supplementation possibly inhibits the high-fat induced change of the adipocytes to TLR2/TNF-alpha co-expressing cells through the action of IGF-1.

References

Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M A HeffernanF M Ng
Dec 16, 2005·The American Journal of the Medical Sciences·Louise Hutley, Johannes B Prins
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Scott M Grundy

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Citations

Jan 11, 2013·Physiological Reviews·André Tchernof, Jean-Pierre Després
Jul 29, 2021·American Journal of Physiology. Cell Physiology·Yoshitaka KubotaNobuyuki Mitsukawa

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