PMID: 7010893Feb 1, 1981Paper

Low-dose heparin in proximal femoral fractures. Failure to prevent deep-vein thrombosis

Acta Orthopaedica Scandinavica
H Svend-HansenP Ostri

Abstract

The effect of heparin, 5000 units every 8 hours, on deep venous thrombosis in patients with proximal femoral fractures was investigated in a controlled, double blind, randomised study. Heparin or placebo was administered as soon as possible after the fracture, and before 6 hours had passed, and was continued for 14 days. The diagnosis of deep venous thrombosis was made using daily I125 fibrinogen scans. A total of 130 patients endured the trial and the results were registered on a sequential diagram. This showed that the 0-hypothesis could not be rejected, and that consequently no difference in the frequency of deep-vein thrombosis was detected.

References

Sep 25, 1971·Lancet·V V KakkarP T Flute
Mar 15, 1973·The New England Journal of Medicine·A S GallusS M Hudecki
May 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·R M BallardT G McCarthy
Jun 1, 1973·The British Journal of Surgery·S A SmyrnisJ K Agnantis
Jul 30, 1973·JAMA : the Journal of the American Medical Association·C M Evarts, R J Alfidi
Jul 21, 1966·The New England Journal of Medicine·E W SalzmanR W DeSanctis

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Citations

Feb 15, 1985·Thrombosis Research·J Z MortensenT Arnfred
Mar 27, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Andrew NicolaidesUNKNOWN International Union of Angiology and Union Internationale du Phlebologie

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