Low-dose human menopausal gonadotrophin versus clomiphene citrate in subfertile couples treated with intrauterine insemination: a randomized controlled trial

Human Reproduction
Karen PeeraerT M D'Hooghe

Abstract

Can controlled ovarian stimulation with low-dose human menopausal gonadotrophin (hMG) improve the clinical pregnancy rate when compared with ovarian stimulation with clomiphene citrate (CC) in an intrauterine insemination (IUI) programme for subfertile couples? Ovarian stimulation with low-dose hMG is superior to CC in IUI cycles with respect to clinical pregnancy rate. IUI after ovarian stimulation is an effective treatment for mild male subfertility, unexplained subfertility and minimal-mild endometriosis, but it is unclear which medication for ovarian stimulation is more effective. A total of 330 women scheduled for IUI during 657 cycles (September 2004-December 2011) were enrolled in an open-label randomized clinical trial to ovarian stimulation with low-dose hMG subcutaneous (n = 334, 37.5-75 IU per day) or CC per oral (n = 323, 50 mg/day from Day 3-7). Assuming a difference of 10% in 'clinical pregnancy with positive fetal heart beat', we needed 219 cycles per group (alpha-error 0.05, power 0.80). We studied subfertile couples with mild male subfertility, unexplained subfertility or minimal-mild endometriosis. Further inclusion criteria were failure to conceive for ≥12 months, female age ≤42 years, at least one patent Fal...Continue Reading

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Jun 23, 2015·Reproductive Biomedicine Online·G BahadurS Okolo
May 14, 2016·Human Fertility : Journal of the British Fertility Society·Bryan WoodwardJackson Kirkman-Brown
Jan 26, 2017·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Minna E GeislerJohn J Waterstone
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Dec 6, 2019·Human Reproduction Update·N A DanhofM H Mochtar
Jan 26, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Isarin ThanaboonyawatPitak Laokirkkiat
Aug 6, 2021·International Journal of General Medicine·Xue WangQing-Chun Li
Nov 6, 2021·The Cochrane Database of Systematic Reviews·Astrid Ep CantineauBen J Cohlen

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