Low dose Intralipid resuscitation improves survival compared to ClinOleic in propranolol overdose in rats

PloS One
Kimberly F MacalaStephane L Bourque

Abstract

Medication overdose is a prevalent issue and despite mixed reports of efficacy, the use of intravenous lipid emulsions, notably Intralipid®, for the management of toxicity from lipid-soluble drugs is becoming increasingly prevalent. Whether alternative lipid emulsion formulations have similar efficacy for resuscitation compared to Intralipid is not known. Here, we compared the efficacy of Intralipid and ClinOleic® for resuscitation following overdose with the lipid-soluble beta-adrenergic antagonist propranolol. Male Sprague-Dawley rats (age 3-4 months) were anesthetized with isoflurane and instrumented for direct hemodynamic assessments. In Study One, rats (n = 22) were pre-treated with Intralipid 20% (n = 12) or ClinOleic 20% (n = 10) to determine whether the hemodynamic effects of propranolol could be prevented. In Study Two, rats were randomly assigned to Intralipid 20% (1, 2, or 3 mL/kg IV, n = 21) or ClinOleic 20% (1, 2, or 3 mL/kg IV, n = 20) resuscitation groups following propranolol overdose (15 mg/kg IV). In Study Three the effect of Intralipid 20% (1 mL/kg IV, n = 3) and ClinOleic 20% (1 mL/kg IV, n = 3) in the absence of propranolol was investigated. The primary endpoint in all studies was survival time (up to a max...Continue Reading

References

Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Hakuo TakahashiMasato Nishimura
Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Grant CaveCraig D Castle
Feb 6, 2009·Anesthesiology·Jean-Xavier MazoitDan Benhamou
Mar 14, 2009·Resuscitation·Amy C YoungKurt C Kleinschmidt
Oct 23, 2009·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Grant Cave, Martyn Harvey
Aug 13, 2011·The Journal of Clinical Endocrinology and Metabolism·Joselita SiqueiraGuillermo E Umpierrez
Oct 13, 2012·The Journal of Pharmacy and Pharmacology·Amira M SenbelTahia T Daabees
Mar 28, 2013·Critical Care Medicine·Michael R FettiplaceGuy Weinberg
Nov 1, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Ravi AgarwalaTimothy J Wiegand
Dec 18, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Michael LevineAnthony F Pizon
Oct 7, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·M St-OngeR Blais
Nov 8, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Kimberly Macala, Reza Tabrizchi
Dec 9, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael R FettiplaceGuy Weinberg
Dec 24, 2014·The Journal of Emergency Medicine·Dazhe CaoAlex Koyfman
Jan 7, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·James B MowryMarsha Ford
Feb 9, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte C G HoegbergUNKNOWN Lipid Emulsion Workgroup
Apr 2, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Bryan D HayesUNKNOWN Lipid Emulsion Workgroup
Apr 29, 2016·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·UNKNOWN American College of Medical Toxicology
Sep 9, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sophie GosselinValéry Lavergne
Mar 28, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Michael R Fettiplace, Daniel J McCabe
Jul 15, 2017·The American Journal of Emergency Medicine·James A ChenowethJohn R Richards
Jan 20, 2018·SSM - Population Health·Christopher J Ruhm

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Software Mentioned

GraphPad Prism
Intralipid
ARRIVE
ClinOleic

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