PMID: 107793May 1, 1979

Low-dose intravenous insulin in the treatment of diabetic ketoacidosis

American Journal of Diseases of Children
M S Kappy, E S Lightner

Abstract

Continuous slow intravenous infusion of insulin was used in 52 episodes of diabetic ketoacidosis. No complications of therapy, ie, hypoglycemia, induced hypokalemia, insulin resistance, or cerebral edema, were encountered. Potassium phosphate was given to 47 of the 52 patients. Sodium bicarbonate was administered to only one patient. The hyperglycemia frequently resolved more rapidly than the systemic acidosis; this was managed by adding glucose to the intravenous fluids when the blood sugar concentration decreased to approximately 250 mg/dL; insulin infusion, however, was continued until the acidosis was corrected (venous standard bicarbonate greater than 14 mEq/L). We have found this method of treatment to be safe and simple to administer, and we believe it is the preferred treatment of patients with diabetic ketoacidosis.

Citations

Dec 4, 2010·Indian Journal of Pediatrics·Sindhu SivanandanRakesh Lodha
Sep 17, 2009·Pediatric Diabetes·J I WolfsdorfRagnar Hanas
Jan 23, 1998·Annals of Emergency Medicine·S M GreenG J Zimmerman

Related Concepts

Parenteral Infusion
Novolin
Diabetic Ketoacidosis

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