Low-dose, ionizing radiation and age-related changes in skeletal microarchitecture.

Journal of Aging Research
Joshua S AlwoodRuth K Globus

Abstract

Osteoporosis can profoundly affect the aged as a consequence of progressive bone loss; high-dose ionizing radiation can cause similar changes, although less is known about lower doses (≤100 cGy). We hypothesized that exposure to relatively low doses of gamma radiation accelerates structural changes characteristic of skeletal aging. Mice (C57BL/6J-10 wk old, male) were irradiated (total body; 0-sham, 1, 10 or 100 cGy (137)Cs) and tissues harvested on the day of irradiation, 1 or 4 months later. Microcomputed tomography was used to quantify microarchitecture of high turnover, cancellous bone. Irradiation at 100 cGy caused transient microarchitectural changes over one month that were only evident at longer times in controls (4 months). Ex vivo bone cell differentiation from the marrow was unaffected by gamma radiation. In conclusion, acute ionizing gamma irradiation at 100 cGy (but not at 1 cGy or 10 cGy) exacerbated microarchitectural changes normally found during progressive, postpubertal aging prior to the onset of age-related osteoporosis.

References

Dec 1, 1992·Journal of Biomechanics·S C Cowin, C H Turner
Jan 1, 1990·Journal of Biomechanics·C H TurnerJ C Rice
Sep 29, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S S VaranasiH K Datta
Jan 1, 1997·Computer Methods in Biomechanics and Biomedical Engineering·TOR Hildebrand, PETER Rüegsegger
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bernard P HalloranSharmila Majumdar
Jan 1, 1997·Angiogenesis·R Bicknell
Oct 14, 2003·Journal of Applied Physiology·Ego Seeman
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jay J CaoBernard P Halloran
Jun 3, 2006·Journal of Applied Physiology·S A HamiltonT A Bateman
May 10, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vaida GlattMary L Bouxsein
Jul 12, 2007·The Journal of Biological Chemistry·Maria AlmeidaStavros C Manolagas
May 23, 2008·Radiation Research·Eric R BandstraTed A Bateman
Sep 4, 2008·Radiation Research·Jeffrey S WilleyTed A Bateman
Oct 31, 2009·Journal of Applied Physiology·Hisataka KondoRuth K Globus
Jun 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mary L BouxseinRalph Müller
Apr 27, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Adam D G Baxter-JonesDonald A Bailey

❮ Previous
Next ❯

Citations

Jan 28, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Ju-Yeon MoonMan Ho Choi
Oct 12, 2013·Journal of Bone and Mineral Metabolism·Lamya Karim, Stefan Judex
Sep 27, 2014·Life Sciences in Space Research·Ann R Kennedy
Nov 9, 2012·International Journal of Radiation Biology·Jeffrey S WilleyRichard F Loeser
Jun 3, 2014·International Journal of Radiation Biology·Ian D HutchinsonJeffrey S Willey
Mar 4, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Joshua S AlwoodRuth K Globus
Dec 26, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nilufer CinkilicRahmi Bilaloglu
Feb 13, 2016·Scientific Reports·A-S SchreursR K Globus
Oct 17, 2017·International Journal of Molecular Sciences·Candice G T Tahimic, Ruth K Globus
Sep 28, 2017·International Journal of Molecular Sciences·Elizabeth A BlaberKaren R Jonscher
Oct 11, 2017·International Journal of Molecular Sciences·Joshua S AlwoodRuth K Globus
Dec 7, 2018·Journal of X-ray Science and Technology·Reem H El-GebalyIslam K Maamoun
Aug 14, 2020·American Journal of Physiology. Cell Physiology·Ann-Sofie SchreursRuth K Globus
Dec 3, 2020·International Journal of Radiation Biology·Marie-Claire UngSabine M Hölter

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.