Low-Dose Iron Supplementation in Infancy Modestly Increases Infant Iron Status at 9 Mo without Decreasing Growth or Increasing Illness in a Randomized Clinical Trial in Rural China

The Journal of Nutrition
B LozoffMing Li

Abstract

Previous trials of iron supplementation in infancy did not consider maternal iron supplementation. This study assessed effects of iron supplementation in infancy and/or pregnancy on infant iron status, illnesses, and growth at 9 mo. Enrollment occurred from December 2009 to June 2012 in Hebei, China. Infants born to women in a pregnancy iron supplementation trial were randomly assigned 1:1 to iron [∼1 mg Fe/(kg · d) as oral iron proteinsuccynilate] or placebo from 6 wk to 9 mo, excluding infants with cord ferritin <35 μg/L. Study groups were pregnancy placebo/infancy placebo (placebo/placebo), pregnancy placebo/infancy iron (placebo/iron), pregnancy iron/infancy placebo (iron/placebo), and pregnancy iron/infancy iron (iron/iron). The primary outcome was 9-mo iron status: iron deficiency (ID) by cutoff (≥2 abnormal iron measures) or body iron <0 mg/kg and ID + anemia (hemoglobin <110 g/L). Secondary outcomes were doctor visits or hospitalizations and weight or length gain from birth to 9 mo. Statistical analysis by intention to treat and dose-response (between number of iron bottles received and outcome) used logistic regression with concomitant RRs and general linear models, with covariate control as applicable. Of 1482 infants...Continue Reading

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Citations

Dec 14, 2017·European Journal of Clinical Nutrition·Denise C C SantosBetsy Lozoff
Mar 21, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Angélique LewiesJeannine Baumgartner
Oct 3, 2017·The British Journal of Nutrition·Staffan K BerglundCristina Campoy
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May 28, 2019·Pediatric Research·Ajibola I AbioyeJennifer F Friedman

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