Low-dose methotrexate-induced pancytopenia.

Clinical Rheumatology
Yogesh Preet SinghVikas Agarwal

Abstract

Methotrexate (MTX) has gained wide acceptance among both patients and rheumatologists due to its efficacy and safe therapeutic window in a variety of inflammatory rheumatological disorders. However, it has the potential to cause serious, life-threatening complications and even mortality. In the present series, we have reviewed our data of five patients who developed serious pancytopenia after the use of MTX, including one who died. Two of these resulted from prescription errors by primary care physicians. The clinical, laboratory, and outcome profile of all five cases are discussed with a brief review of the literature about MTX-induced pancytopenia. There is an urgent need to increase awareness in primary care physicians, patients, and pharmacists toward informed prescribing, dispensing, and monitoring of MTX to prevent such mishaps in the future.

References

Feb 1, 1996·Arthritis and Rheumatism·S Gutierrez-UreñaL R Espinoza
Nov 15, 1997·Rheumatic Diseases Clinics of North America·R J McKendry
Feb 1, 2003·BMJ : British Medical Journal·Michael Sosin, Sunil Handa
Jun 10, 2004·The Annals of Pharmacotherapy·Jonathan ChanPeter I Pillans

❮ Previous
Next ❯

Citations

Jul 17, 2014·Reumatología clinica·Lorena Expósito PérezSagrario Bustabad Reyes
Apr 25, 2009·Journal of the American Academy of Dermatology·Robert E KalbMark Lebwohl
Nov 14, 2014·Immunologic Research·Vasco C RomãoJoão Eurico Fonseca
Jun 5, 2015·Geriatric Nursing·William Simonson
Jul 13, 2016·Drugs & Aging·Su-Ann YeohRichard Hull
Aug 31, 2016·American Journal of Therapeutics·Antonella MameliFrancesco Marongiu
Nov 11, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·P Brandon BookstaverJames Fant
Jun 5, 2020·Journal of Comparative Effectiveness Research·Zahra BagheriHossein Khalili
Aug 4, 2012·Biomedit︠s︡inskai︠a︡ khimii︠a︡·V N Zinov'eva, A A Spasov
Jun 4, 2016·The Medical Journal of Australia·Rose CairnsNicholas A Buckley
Jul 30, 2018·Clinical Rheumatology·Döndü Üsküdar CansuCengiz Korkmaz
Mar 7, 2017·International Journal of Rheumatic Diseases·Sajal AjmaniVikas Agarwal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.