Low-Dose Metronidazole is Associated With a Decreased Rate of Endoscopic Recurrence of Crohn's Disease After Ileal Resection: A Retrospective Cohort Study

Journal of Crohn's & Colitis
Laura R GlickDavid T Rubin

Abstract

Recurrence of Crohn's disease after surgical resection and primary anastomosis is an important clinical challenge. Previous studies have demonstrated the benefit of imidazole antibiotics, but have been limited by adverse events and medication intolerance. We evaluated whether administration of low-dose metronidazole [250 mg three times per day] for 3 months reduces endoscopic postoperative recurrence rates. We performed a retrospective cohort study of patients with Crohn's disease who underwent ileal resection with a primary anastomosis and subsequently received care at our center. We compared the cases who received low-dose metronidazole for 3 months with control patients who did not receive this therapy. Data collected included demographics, risk factors for recurrence, and medications before and after surgery. The primary end point was the number of patients with ≥i2 [Rutgeerts] endoscopic recurrence by 12 months. Variables found to be predictive in univariate analysis at p < 0.10 were introduced in the Cox model for multivariate analysis. In all, 70 patients with Crohn's disease [35 cases and 35 controls] met inclusion criteria. Risk factors for Crohn's recurrence were similar between groups. The number of patients with ≥i2...Continue Reading

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Citations

Apr 19, 2020·Current Opinion in Gastroenterology·Edward L Barnes
Feb 15, 2020·Drugs·Lucine Vuitton, Laurent Peyrin-Biroulet
Jun 23, 2020·Gut Microbes·Amy L HamiltonShu-Mei Teo
Oct 8, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Edward L BarnesMiguel Regueiro
Feb 2, 2021·World Journal of Clinical Cases·Lie Zheng, Xin-Li Wen
Mar 2, 2021·Therapeutic Advances in Gastroenterology·Ravi S Shah, Benjamin H Click

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