Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy

Brain Research
B KüçükkayaA S Yalçin

Abstract

We have used chemiluminescence measurements to examine the relationship between free radical formation and excitotoxicity in a post-traumatic epilepsy model. For this purpose, seven days after injecting iron in rat brain cortices, we measured luminol- and lucigenin-enhanced chemiluminescence in different brain regions (ipsilateral cortex, contralateral cortex, hypothalamus and hippocampus). In all brain regions (except contralateral cortices) both luminol- and lucigenin-enhanced chemiluminescence were increased in iron-injected group compared to saline-injected control group. These increases returned to control values in iron-injected rats pretreated with MK-801. Our results suggest that both free radicals and excitatory amino acids play important roles in the development of post-traumatic epilepsy and that MK-801 has protective effects against iron-induced chemiluminescence formation.

References

Jan 1, 1990·Methods in Enzymology·R L LevineE R Stadtman
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L J Willmore, W J Triggs
Jan 1, 1989·Free Radical Biology & Medicine·F P CorongiuM A Dessi
May 1, 1995·Pharmacology, Biochemistry, and Behavior·E L Hargreaves, D P Cain
Jan 31, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·G HaklarA S Yalçin
Oct 29, 1993·Science·J T Coyle, P Puttfarcken

❮ Previous
Next ❯

Citations

May 3, 2012·The Neurologist·Pedro Beleza
Jun 14, 2000·Drugs·A Iudice, L Murri
Oct 24, 2009·Epilepsy Research·Simon Waldbaum, Manisha Patel
Mar 30, 2016·Epilepsy Research·Rohan MahaleRangasetty Srinivasa
May 30, 2006·Brain Research·Takeshi IwazakiIzuru Matsumoto
Sep 10, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·James C GuthMatthew B Maas
Jul 31, 2012·Seizure : the Journal of the British Epilepsy Association·Jayantee KalitaUsha Kant Misra
Sep 24, 1999·Journal of Neuroscience Research·T A SarafianH Shau
May 28, 2017·Pathophysiology : the Official Journal of the International Society for Pathophysiology·David E ConnorJ Steven Alexander
Dec 21, 2018·Journal of Neurology·Jayantee KalitaDeepanshu Dubey
Sep 7, 2018·Epilepsia Open·Jafar Mehvari HabibabadiNasim Tabrizi
Mar 5, 2021·Journal of Epilepsy Research·Gourav Goyal, Rambir Singh
Jan 27, 2017·Translational Neuroscience·Wen-Jing XieHong-Mei Meng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.