Low dose nitrite improves reoxygenation following renal ischemia in rats

Scientific Reports
Kathleen CantowErdmann Seeliger

Abstract

In hypoxic and acidic tissue environments, nitrite is metabolised to nitric oxide, thus, bringing about novel therapeutic options in myocardial infarction, peripheral artery disease, stroke, and hypertension. Following renal ischemia, reperfusion of the kidney remains incomplete and tissue oxygenation is reduced for several minutes to hours. Thus, in renal ischemia-reperfusion injury, providing nitrite may have outstanding therapeutic value. Here we demonstrate nitrite's distinct potential to rapidly restore tissue oxygenation in the renal cortex and medulla after 45 minutes of complete unilateral kidney ischemia in the rat. Notably, tissue oxygenation was completely restored, while tissue perfusion did not fully reach pre-ischemia levels within 60 minutes of reperfusion. Nitrite was infused intravenously in a dose, which can be translated to the human. Specifically, methaemoglobin did not exceed 3%, which is biologically negligible. Hypotension was not observed. Providing nitrite well before ischemia and maintaining nitrite infusion throughout the reperfusion period prevented the increase in serum creatinine by ischemia reperfusion injury. In conclusion, low-dose nitrite restores renal tissue oxygenation in renal ischemia repe...Continue Reading

References

Nov 10, 2005·American Journal of Physiology. Renal Physiology·Mahesh BasireddyAnupam Agarwal
Jan 13, 2006·Nature Chemical Biology·Mark T GladwinJon O Lundberg
Jan 5, 2007·Journal of the American Society of Nephrology : JASN·Pinpat TripataraChristoph Thiemermann
Jan 24, 2008·Circulation·Abdul R MaherMichael P Frenneaux
Sep 3, 2010·American Journal of Physiology. Renal Physiology·Maarten G SnoeijsL W Ernest van Heurn
Oct 13, 2010·Annual Review of Physiology·Jeffrey L GarvinPablo A Ortiz
Apr 3, 2012·Meat Science·Deepa K Parthasarathy, Nathan S Bryan
May 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Samuel N HeymanChristian Rosenberger
Nov 22, 2012·Clinical and Experimental Pharmacology & Physiology·Roger G EvansBruce S Gardiner
Aug 21, 2013·The Journal of Surgical Research·Miniwan TulafuMakoto Tomita
Mar 7, 2014·American Journal of Physiology. Renal Physiology·Amany AbdelkaderRoger G Evans
Apr 7, 2015·Free Radical Biology & Medicine·Ming LiuMattias Carlström
Jan 16, 2016·Annual Review of Medicine·Anna Zuk, Joseph V Bonventre
Feb 1, 2017·Nitric Oxide : Biology and Chemistry·Stephan KemmnerChristoph Schmaderer
Feb 1, 2017·Nature Reviews. Nephrology·Michael FählingPontus B Persson

❮ Previous
Next ❯

Citations

Sep 3, 2019·Frontiers in Neurology·Şefik Evren Erdener, Turgay Dalkara
Nov 21, 2019·Biological Chemistry·Matthew B AmdahlMark T Gladwin
Dec 27, 2019·Acta Physiologica·Thoralf NiendorfAndreas Pohlmann
Dec 29, 2020·Redox Biology·Gensheng ZhangMattias Carlstrom
Feb 7, 2021·Nature Reviews. Nephrology·Holger ScholzPontus B Persson
Jun 24, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yoshihiro TangeShigenori Yoshitake

❮ Previous
Next ❯

Software Mentioned

Number Cruncher

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.