Low Dose of Apelin-36 Attenuates ER Stress-Associated Apoptosis in Rats with Ischemic Stroke

Frontiers in Neurology
Jian QiuBo Bai

Abstract

Cerebral ischemia/reperfusion (I/R) injury-induced cellular apoptosis contributes to neuronal death in ischemic stroke, while endoplasmic reticulum stress (ERS) and subsequently triggered unfolded protein response (UPR) are the major mechanisms of cerebral I/R injury-induced apoptosis. A number of studies indicated that apelin-13 protects neurons from I/R injury-induced apoptosis. Apelin-36, the longest isoform of apelin, has stronger affinity to apelin receptor than apelin-13 does. However, the role of apelin-36 in ischemic stroke is less studied. In addition, preventive administration of apelin was applied in most studies, which could not precisely reflect its therapeutic potential in ischemic stroke. Here, we first reported that low dose of apelin-36, other than apelin-13, administrated after ischemic stroke significantly reduced infarct volume in rats. Moreover, apelin-36 attenuated cerebral I/R injury-induced apoptosis and caspase-3 activation. Furthermore, apelin-36 suppressed I/R injury-induced CHOP and GRP78 elevation, indicating that apelin-36 inhibited ERS/UPR activation. Our study first demonstrated that post-stroke administration of low-dose apelin-36 could attenuate cerebral I/R injury-induced infarct and apoptosis...Continue Reading

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Citations

Jun 30, 2019·Journal of Cellular Physiology·Huaiqing LuoJin Xu
Jun 15, 2018·International Journal of Molecular Medicine·Yunlu JiangBo Bai
Jul 3, 2019·Frontiers in Neurology·Yanjun TianYili Wu
Aug 6, 2019·Frontiers in Cellular Neuroscience·Kaixin QiuYili Wu
Jul 2, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xiaobo ZhangBingru Fei
Apr 2, 2020·Frontiers in Pharmacology·Shuang-Yu LvYan-Dong Wang
Oct 22, 2019·Frontiers in Molecular Neuroscience·Bingyuan JiYili Wu
Mar 1, 2021·Neuropeptides·Jia-Xiu ZhouShao-Wen Tian
Dec 7, 2020·Journal of Molecular and Cellular Cardiology·Yanqing LiXu Teng
Jun 12, 2021·Journal of Neuroscience Research·Efthalia AngelopoulouChristina Piperi

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

Pro Plus
Pro Plus VERSion
GraphPad Prism
Image

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