Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation

Neuropsychiatric Disease and Treatment
Yuki OmoriTetsuo Shimizu

Abstract

Delayed sleep phase syndrome (DSPS) is a chronic dysfunction of circadian rhythm of the subject that impairs functioning in social, occupational, or other spheres. High rate of depression is found among DSPS patients. Aripiprazole (APZ), a second-generation antipsychotic, is effective in treatment of depression as well as schizophrenia. Recently, few case reports show the effectiveness of APZ in treating DSPS and non-24-hour sleep-wake rhythm disorder. Therefore, we tried to treat DSPS with depression using APZ. Twelve subjects (including four women) aged 19-64 years were included. The subjects were prescribed initially 0.5-3 mg of APZ once a day with subsequent dose adjustments. Sleep onset, midpoint of sleep, and sleep offset were significantly advanced by 1.1, 1.8, and 2.5 hours, respectively. Unexpectedly, sleep duration became significantly shorter by 1.3 hours after treatment. Their depressive moods showed an unremarkable change. Low dose of APZ advanced the sleep rhythm and reduced nocturnal sleep time in the subjects with DSPS. Since it is not easy for physicians to treat prolonged sleep duration often associated with DSPS, this medication would become a new therapeutic option for these patients.

Citations

Jan 22, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Masahiro TakeshimaTakashi Kanbayashi
Jul 30, 2019·Molecular Systems Biology·Dae Wook KimJae Kyoung Kim
Feb 24, 2021·Expert Opinion on Pharmacotherapy·Shohei NishimonSeiji Nishino
Nov 6, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eunsoo MoonOuti Linnaranta
Jul 30, 2021·Psychiatry and Clinical Neurosciences·Aya ImanishiHideaki Kondo

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