Abstract
The aim of this study was to test whether a low dose of interferon-α-2b (IFN-α2b) enhances the clinical outcome of docetaxel (DXT) in patients with castration-resistant prostate cancer (CRPC). A prospective controlled trial of 40 CRPC patients receiving 5 mg of prednisone twice daily was conducted, where patients were randomly assigned to be administered 75 mg/m(2) DXT plus 3 mIU/m(2) IFN-α2b (group A, n=20) or 75 mg/m(2) DXT alone (group B, n=20). The prostate-specific antigen (PSA) response, tumor response, progression-free survival (PFS) and overall survival (OS) were evaluated. There was no statistically significant difference in PSA response rate between groups A and B (65 vs. 47.4%, P=0.341). The tumor response rate in group A was significantly greater compared with that in group B (55 vs. 21.1%, P=0.048). The median PFS was longer in group A compared with that in group B (10 vs. 8 months, P=0.043). There was no statistically significant difference in median OS between the two groups (19 vs. 17 months, P=0.348), but one patient displayed a complete tumor response in group A. In groups A and B, transient grade 3 to 4 neutropenia was observed in nine and six patients, grade 3 to 4 anemia was observed in three and five patie...Continue Reading
References
Nov 1, 1992·Cancer·C M van Haelst-PisaniP A Burch
Dec 1, 1986·Journal of Interferon Research·A Y ChangL Boros
Dec 1, 1986·Journal of Surgical Oncology·M A BulbulG P Murphy
Jun 1, 1993·Virology·D LeprinceD Stehelin
Nov 16, 2001·The British Journal of Radiology·A R Padhani, L Ollivier
Mar 20, 2002·Nature Reviews. Cancer·B J Feldman, D Feldman
Apr 17, 2002·Endocrinology·Partha P BanerjeeTerry R Brown
Sep 12, 2002·Cellular and Molecular Life Sciences : CMLS·A N MakarovskiyW Akerley
Jul 26, 2003·Oncogene·Theocharis PanaretakisDan Grandér
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert J ten TijeSharyn D Baker
May 20, 2005·World Journal of Gastroenterology : WJG·Panasiuk AnatolPanasiuk Bozena
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenneth J Pienta, Deborah Bradley
Jan 26, 2007·Nature·Andrea VenturaTyler Jacks
Oct 12, 2007·Journal of Viral Hepatitis·J KoiralaN M Khardori
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominik R BertholdIan F Tannock
Apr 3, 2009·BJU International·Laurel Emerson, Alvaro Morales
Feb 25, 2010·Journal of Translational Medicine·Robert S DiPaolaGeorge Wilding
Feb 25, 2010·Journal of the National Cancer Institute·Simone MocellinDonato Nitti
Nov 16, 2010·The Journal of Urology·Henry M RosevearMichael A O'Donnell
Dec 2, 2011·Japanese Journal of Clinical Oncology·Nobuo ShinoharaKatsuya Nonomura
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William Kevin KellyEric J Small
Sep 22, 2012·The Prostate·Chengfei LiuAllen C Gao
Citations
Sep 16, 2014·Frontiers in Immunology·Danushka Kumara WijesundaraCharani Ranasinghe
Jun 2, 2015·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Oct 21, 2014·The Prostate·Shanora G BrownJaideep Chaudhary
Mar 2, 2017·Journal of Endocrinological Investigation·A DicitoreG Vitale