PMID: 9447858Feb 3, 1998Paper

Low-dose ondansetron with dexamethasone more effectively decreases vomiting after strabismus surgery in children than does high-dose ondansetron

Anesthesiology
W M Splinter, E J Rhine

Abstract

Ondansetron and dexamethasone have been observed to decrease the incidence of vomiting by children after general anesthesia. This study compared the effect of high-dose (150 microg/kg) ondansetron with low-dose (50 microg/kg) ondansetron plus 150 microg/kg dexamethasone on the incidence of vomiting after strabismus in children. This study had a double-blind, blocked, stratified, randomized design. With parental consent and Hospital Ethics Committee approval, healthy children aged 2-14 yr who were undergoing elective strabismus surgery were studied. Anesthesia was induced intravenously with propofol or by inhalation with halothane and nitrous oxide. Patients in the high-dose group were given placebo plus 150 microg/kg (maximum dose, 8 mg) of ondansetron intravenously, whereas patients in the low-dose group were given 150 microg/kg dexamethasone (maximum dose, 8 mg) and 50 microg/kg ondansetron intravenously in a double-blind manner. Anesthesia was maintained with halothane and nitrous oxide. All incidences of vomiting occurring as long as 24 h after anesthesia were recorded. Three of the 200 patients enrolled in the study were excluded from data analysis. The groups were similar with respect to demographic data and potential con...Continue Reading

References

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Citations

Apr 16, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Amy Rodgers, Robin G Cox
Nov 2, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rebecca E McIntyreRobin G Cox
Sep 16, 2000·Anesthesiology Clinics of North America·L G Maxwell, M Yaster
Jan 11, 2001·Acta Anaesthesiologica Scandinavica·M SaiahG Klainguti
Jul 5, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ayla A KabalakNermin Gogus
Oct 24, 2003·International Anesthesiology Clinics·Christian C Apfel, Norbert Roewer
Oct 24, 2003·International Anesthesiology Clinics·Olutoyin Olutoye, Mehernoor F Watcha
Oct 24, 2003·International Anesthesiology Clinics·Ashraf S Habib, Tong J Gan
May 23, 2008·The Clinical Journal of Pain·Ibrahim Abu-Shahwan
Jul 2, 1999·Anesthesia and Analgesia·J J WangY Y Chia
Dec 10, 1999·Anesthesia and Analgesia·P F White, M F Watcha
Feb 28, 2001·Anesthesia and Analgesia·M T AouadA S Baraka
Dec 22, 2005·Anesthesia and Analgesia·Ali MovafeghAlipasha Meysamie
Nov 29, 2007·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
Dec 21, 2013·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
Oct 23, 2002·Paediatric Drugs·Pasquale De Negri, Giorgio Ivani
Feb 13, 2007·Paediatric Drugs·Anthony L Kovac
Jan 8, 2011·Orthopedics·Jamie CraigKevin Hatton
Oct 4, 2006·Current Opinion in Anaesthesiology·J ScholzP H Tonner
Jul 31, 2004·Paediatric Anaesthesia·Varol CelikerUlkü Aypar
Jun 6, 2000·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·J B Learman
Apr 2, 2003·Expert Opinion on Pharmacotherapy·Ashraf S Habib, Tong J Gan
Mar 15, 2002·Anesthesiology Clinics of North America·Allison Kinder Ross, John B Eck
Apr 12, 2000·Cancer Control : Journal of the Moffitt Cancer Center·R Miguel
Mar 30, 2017·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·M R RazavizadehF Atoof
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson
Apr 20, 2004·Journal of Pediatric Ophthalmology and Strabismus·Neerja BhardwajPramila Chari

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