Low-dose oral contraceptive usage and coagulation

American Journal of Obstetrics and Gynecology
M NotelovitzR Carter

Abstract

A prospective investigation was initiated to assess the effect of a low-dose oral contraceptive containing 35 micrograms of ethinyl estradiol and 0.4 mg of norethindrone on blood coagulation and fibrinolysis. Twenty-four women were studied before, during, and after one year of treatment. Positive results included an accelerated activated partial thromboplastin time and an increase in fibrinolytic and anticoagulation factors as measured by alpha 1-antitrypsin antigen and plasminogen antigen and activity. Antithrombin III antigen was decreased but its activity was unaffected. There was no evidence of ongoing intravascular coagulation. No patient had a detectable thromboembolic event. In short, one year's usage of this low-dose oral contraceptive was not associated with a procoagulant hematologic profile.

Citations

Jul 1, 1987·Journal of General Internal Medicine·R Cygan, H Waitzkin
Aug 11, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A O AisienM O Shobowale
Mar 1, 1990·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K SinghS S Ratnam
Dec 31, 1997·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C P SpencerJ C Stevenson
May 1, 1994·Journal of Clinical Pharmacology·S M FortneyC Alfrey
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·M NozakiH Nakano
Sep 1, 1995·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·M J Werner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.