Low-dose oral prednisone improves clinical and ultrasonographic remission rates in early rheumatoid arthritis: results of a 12-month open-label randomised study.

Arthritis Research & Therapy
Carlomaurizio MontecuccoRoberto Caporali

Abstract

In early rheumatoid arthritis (RA), low-dose oral prednisone (PDN) co-medication yields better clinical results than monotherapy with disease-modifying anti-rheumatic drugs (DMARDs). In addition, ultrasonography (US) evaluation reveals rapid and significant effects of glucocorticosteroids on subclinical synovitis. No data currently exist that examine the clinical and US results offered by glucocorticoid co-medication over DMARD monotherapy in early RA patients. Two hundred and twenty patients with early RA (< 1 year from clinical onset) were treated according to a low disease activity (LDA) targeted step-up protocol including methotrexate (MTX) and, in the active treatment arm, low-dose (6.25 mg/day) oral PDN over 12 months. Clinical disease activity measures were collected at baseline, 2, 4, 6, 9 and 12 months, and US examination of hands was performed at baseline, 6 and 12 months. Grey-scale and power Doppler (PD) synovitis were scored (0 to 3) for each joint. At 12 months, clinical remission according to the disease activity score among 28 joints was defined as the clinical outcome, and a total joint PD score of 0 (PD negativity) as the imaging outcome. Each group included 110 patients with comparable demographic, clinical, ...Continue Reading

References

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Citations

Jan 22, 2013·Drugs·Roberto CaporaliCarlomaurizio Montecucco
Apr 11, 2014·Expert Review of Clinical Immunology·Marco Krasselt, Christoph Baerwald
Nov 8, 2015·Arthritis Care & Research·Jasvinder A SinghTimothy McAlindon
Nov 8, 2015·Arthritis & Rheumatology·Jasvinder A SinghTimothy McAlindon
May 13, 2014·Annals of the New York Academy of Sciences·Tânia Santiago, José António P da Silva
May 16, 2014·Annals of the New York Academy of Sciences·Cécile Gaujoux-Viala, Laure Gossec
Sep 18, 2013·European Journal of Internal Medicine·Oscar EpisEnrico Tirri
Jun 6, 2013·Advances in Pharmacological Sciences·Marinella PatanèEmilio Russo
Nov 17, 2014·Rheumatology International·Halil HarmanSibel Harman
May 7, 2019·Expert Opinion on Drug Safety·Mariana LuísTânia Santiago
Jul 30, 2020·European Journal of Clinical Investigation·Marco FornaroFlorenzo Iannone
Jan 19, 2019·Advances in Rheumatology·Licia Maria Henrique da MotaRina Dalva Neubarth Giorgi
Jul 15, 2016·Zeitschrift für Rheumatologie·E Gromnica-Ihle
Jun 7, 2020·Zeitschrift für Rheumatologie·M SchneiderC Specker
Jun 8, 2021·Therapeutic Advances in Musculoskeletal Disease·Serena BugattiCarlomaurizio Montecucco
Apr 15, 2015·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Shawn C Roll

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