Abstract
In early rheumatoid arthritis (RA), low-dose oral prednisone (PDN) co-medication yields better clinical results than monotherapy with disease-modifying anti-rheumatic drugs (DMARDs). In addition, ultrasonography (US) evaluation reveals rapid and significant effects of glucocorticosteroids on subclinical synovitis. No data currently exist that examine the clinical and US results offered by glucocorticoid co-medication over DMARD monotherapy in early RA patients. Two hundred and twenty patients with early RA (< 1 year from clinical onset) were treated according to a low disease activity (LDA) targeted step-up protocol including methotrexate (MTX) and, in the active treatment arm, low-dose (6.25 mg/day) oral PDN over 12 months. Clinical disease activity measures were collected at baseline, 2, 4, 6, 9 and 12 months, and US examination of hands was performed at baseline, 6 and 12 months. Grey-scale and power Doppler (PD) synovitis were scored (0 to 3) for each joint. At 12 months, clinical remission according to the disease activity score among 28 joints was defined as the clinical outcome, and a total joint PD score of 0 (PD negativity) as the imaging outcome. Each group included 110 patients with comparable demographic, clinical, ...Continue Reading
References
Mar 1, 1988·Arthritis and Rheumatism·F C ArnettH S Luthra
Feb 1, 1986·British Journal of Rheumatology·P T DawesM F Shadforth
Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Jul 20, 1995·The New England Journal of Medicine·J R Kirwan
Jan 1, 1995·Arthritis and Rheumatism·M L PrevooP L van Riel
Aug 2, 1997·Lancet·M BoersS van der Linden
Jan 13, 2001·Zeitschrift für Rheumatologie·J R Kirwan
Jun 19, 2001·Annals of the Rheumatic Diseases·M BackhausUNKNOWN Working Group for Musculoskeletal Ultrasound in the EULAR Standing Committee on International Clinical Studies including The
Jan 5, 2002·Annals of Internal Medicine·Amalia A van EverdingenJohannes W J Bijlsma
Feb 7, 2003·Arthritis and Rheumatism·Richard J WakefieldPaul Emery
Jul 2, 2003·Rheumatology·E MorrisonH A Capell
Oct 30, 2003·Annals of the Rheumatic Diseases·L TerslevH Bliddal
May 14, 2004·Annals of the Rheumatic Diseases·E FilippucciW Grassi
Feb 15, 2005·Annals of the Rheumatic Diseases·E NaredoA Laffon
Oct 29, 2005·Arthritis and Rheumatism·Björn SvenssonIngiäld Hafström
Oct 29, 2005·Arthritis and Rheumatism·Siegfried WassenbergHenning Zeidler
Nov 1, 2005·Arthritis and Rheumatism·Y P M Goekoop-RuitermanB A C Dijkmans
Jul 21, 2006·Annals of the New York Academy of Sciences·Johannes W J BijlsmaJohannes W G Jacobs
Jul 21, 2006·Annals of the New York Academy of Sciences·José A P Da SilvaJohannes W J Bijlsma
Nov 30, 2006·Arthritis and Rheumatism·A K BrownP Emery
May 24, 2007·Annals of the Rheumatic Diseases·S M M VerstappenUNKNOWN Utrecht Rheumatoid Arthritis Cohort study group
Jul 31, 2007·Annals of the Rheumatic Diseases·J N HoesJ W J Bijlsma
Apr 3, 2008·Arthritis and Rheumatism·Esperanza NaredoUNKNOWN Ultrasound Group of The Spanish Society of Rheumatology
Jun 30, 2009·Rheumatology·Carlo A ScirèRoberto Caporali
Jul 1, 2009·Arthritis and Rheumatism·Benazir SaleemPaul Emery
Jan 6, 2010·Rheumatology·Alejandro BalsaEmilio Martín-Mola
Mar 11, 2010·Annals of the Rheumatic Diseases·Josef S SmolenUNKNOWN T2T Expert Committee
May 18, 2010·Annals of the Rheumatic Diseases·Hilde Berner HammerTore K Kvien
Aug 10, 2010·Annals of the Rheumatic Diseases·M C van der GoesJ W J Bijlsma
Oct 5, 2010·The Journal of Rheumatology·Maggie J LarchéPeter C Taylor
Feb 5, 2011·Arthritis and Rheumatism·David T FelsonUNKNOWN European League Against Rheumatism
Jun 8, 2011·Arthritis and Rheumatism·Marloes VermeerMart A F J van de Laar
Jul 28, 2011·Arthritis and Rheumatism·Ziga RotarMatija Tomšič
Citations
Jan 22, 2013·Drugs·Roberto CaporaliCarlomaurizio Montecucco
Jan 9, 2014·Arthritis Research & Therapy·Julio RamírezJuan D Cañete
Jan 8, 2014·Annals of the Rheumatic Diseases·Cécile Gaujoux-VialaLaure Gossec
Apr 15, 2014·Rheumatology·Arthur Kavanaugh, Alvin F Wells
Apr 11, 2014·Expert Review of Clinical Immunology·Marco Krasselt, Christoph Baerwald
Nov 8, 2015·Arthritis Care & Research·Jasvinder A SinghTimothy McAlindon
Nov 8, 2015·Arthritis & Rheumatology·Jasvinder A SinghTimothy McAlindon
Jul 2, 2014·Experimental Dermatology·George ManMao-Qiang Man
May 13, 2014·Annals of the New York Academy of Sciences·Tânia Santiago, José António P da Silva
May 16, 2014·Annals of the New York Academy of Sciences·Cécile Gaujoux-Viala, Laure Gossec
Sep 18, 2013·European Journal of Internal Medicine·Oscar EpisEnrico Tirri
Mar 17, 2015·Clinical Rheumatology·Claiton Viegas BrenolRicardo Machado Xavier
Jun 6, 2013·Advances in Pharmacological Sciences·Marinella PatanèEmilio Russo
Feb 11, 2015·Rheumatology International·Katinka AlbrechtAngela Zink
Nov 17, 2014·Rheumatology International·Halil HarmanSibel Harman
Jun 30, 2016·Rheumatology·Emanuela BellisAnnamaria Iagnocco
Mar 5, 2016·Annals of the Rheumatic Diseases·Cindy StrehlFrank Buttgereit
Oct 8, 2016·Arthritis Research & Therapy·Serena BugattiRoberto Caporali
Jul 14, 2017·Modern Rheumatology·Shuji AsaiToshihisa Kojima
Dec 6, 2017·Health Technology Assessment : HTA·Allan WailooAdam Young
May 7, 2019·Expert Opinion on Drug Safety·Mariana LuísTânia Santiago
Jul 30, 2020·European Journal of Clinical Investigation·Marco FornaroFlorenzo Iannone
Jan 19, 2019·Advances in Rheumatology·Licia Maria Henrique da MotaRina Dalva Neubarth Giorgi
Jul 15, 2016·Zeitschrift für Rheumatologie·E Gromnica-Ihle
Jul 8, 2020·Medicine·Li HuaXiaowei Shi
Jun 7, 2020·Zeitschrift für Rheumatologie·M SchneiderC Specker
Jun 6, 2018·Frontiers in Medicine·Serena BugattiAntonio Manzo
Apr 19, 2019·Arthritis Research & Therapy·Xiaoying SunZhuoli Zhang
Apr 8, 2021·PloS One·Mariana Del Grossi PagliaCristiane de Cássia Bergamaschi
Jun 8, 2021·Therapeutic Advances in Musculoskeletal Disease·Serena BugattiCarlomaurizio Montecucco
Jul 2, 2021·Frontiers in Immunology·Serena BugattiCarlomaurizio Montecucco
Jul 22, 2021·ACR Open Rheumatology·Tariq ChukirEmily Stein
Aug 11, 2021·Advances in Rheumatology·John M StacyErdal Diri
Apr 15, 2015·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Shawn C Roll