Low-dose propofol ameliorates haemorrhagic shock-induced organ damage in conscious rats

Clinical and Experimental Pharmacology & Physiology
Chung-Jen LeeBang Gee Hsu

Abstract

1. Propofol is an anti-inflammatory agent commonly used for general anaesthesia and sedation in intensive care unit patients. Haemorrhagic shock (HS) followed by resuscitation can induce the production of several inflammatory mediators, such as tumour necrosis factor (TNF)-a and interleukin (IL)-10, leading to multiple organ dysfunction and death. 2. In the present study, we investigated the effects of treatment with high-dose (10 mg/kg per h) and low-dose (1 mg/kg per h) propofol after HS on the physiopathology and cytokine levels in conscious rats. 3. The experiments were designed to induce HS by withdrawing 40% of total blood volume from a femoral artery catheter (6 mL/100 g bodyweight) over 30 min. Mean arterial pressure (MAP) and heart rate (HR) were monitored continuously for 48 h after the start of blood withdrawal. Levels of biochemical parameters, including glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), creatinine, creatine phosphokinase (CPK) and lactate dehydrogenase (LDH), were measured 30 min before and 0, 1, 3, 6, 9, 12, 18, 24 and 48 h after the end of the 30 min blood withdrawal period. Serum cytokine levels, including TNF-a and IL-10, were measured at 1,...Continue Reading

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Citations

Jan 1, 2013·Journal of Anesthesia·Iosifina I KarmaniolouNikolaos F Arkadopoulos
Jun 12, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Irene RiezzoVittorio Fineschi
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Silke LeonhardtDaniel Seehofer
Dec 24, 2009·Biological Research for Nursing·Tai-Chu PengRu-Ping Lee
Jun 28, 2012·Molecular Medicine Reports·Zhen LiZhipeng Wang
Nov 26, 2009·The Journal of Surgical Research·Fwu-Lin YangBang-Gee Hsu

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