PMID: 6978924Jun 1, 1982Paper

Low dose radiosensitivity of alloimmune cytotoxic T cells

The Journal of Experimental Medicine
C Spellman, R E Anderson

Abstract

Low dose radiosensitivity of in vitro generated alloimmune murine cytotoxic T lymphocytes (CTL) was studied. It appears that a subset of CTL exists that can be killed with 10-25 rad of x rays. These radiosensitive CTL are Lyt-1,2+ T lymphocytes. Analyses of cytotoxicity by chromium release assays indicate that the radiosensitive CTL are present in responder spleen cell cultures from all strains of mice tested. The generation of these effector cells is most pronounced in animals of the C57BL background. The mechanism of low dose radiosensitivity appears to be interphase death.

References

Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G DennertJ F Warner

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Citations

Jan 1, 1985·Immunology Letters·M GerberA Crastes de Paulet
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·Y NakayamaN Ohsawa
Oct 4, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshio Hosoi
May 1, 1993·International Journal of Radiation Biology·Y HosoiK Sakamoto
Aug 9, 2007·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C ThomasN Foray
Oct 22, 2003·Journal of Experimental Therapeutics & Oncology·Akmal SafwatMarianne Hokland
Jan 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R E AndersonS Tokuda
Jan 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C C StewartR C Habbersett

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