Low-dose radiotherapy and concurrent FOLFIRI-bevacizumab: a Phase II study

Future Oncology
Alessio G MorgantiVincenzo Valentini

Abstract

Low-dose radiation therapy (LDRT) can increase biological efficacy of chemotherapy. This Phase II trial evaluates LDRT plus FOLFIRI-bevacizumab (FOLFIRI-B) in metastatic colorectal cancer. raising the clinical complete response rate from 5 to 25%. toxicity, progression-free survival. Patients underwent 12 FOLFIRI-B cycles plus two daily LDRT fractions (20 cGy/6 h interval) on each cycle. Statistical analysis was planned on 18 patients. Results on 18 patients are reported. Specifically considering irradiated sites: 15/18 patients had a partial (11/18) or complete (4/18) response. Among 11 partial responders, three became a pathological CR after surgery. Grade 3-4 toxicity was recorded in two patients (11.1%). At median follow-up of 30 months (range: 8-50), 7/18 patients progressed in irradiated sites. Seven out of 18 patients (38.9%) had clinical or pathological CR in lesions treated with LDRT. Further studies on this newer treatment modality seem justified.

References

Mar 1, 1989·Controlled Clinical Trials·R Simon
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H YoungP Price
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·M C JoinerI Turesson
Apr 3, 2003·International Journal of Cancer. Journal International Du Cancer·Patrick D BeauchesneRémy M Pedeux
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew Arnold, Alexandros Papanikolaou
Feb 6, 2007·International Journal of Radiation Oncology, Biology, Physics·William F RegineMohammed Mohiuddin
Jul 23, 2008·The Journal of Pharmacy and Pharmacology·Aoife M Shannon, Kaye J Williams
Aug 15, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alessio G MorgantiVincenzo Valentini
Jun 23, 2009·International Journal of Radiation Oncology, Biology, Physics·Vincenzo ValentiniLuigia Nardone
Jun 25, 2010·PloS One·Inês Sofia ValaSusana Constantino Rosa Santos
Mar 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MalvezziE Negri
Jan 17, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M BalducciV Valentini
Dec 3, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Andre KonskiSteven J Cohen

❮ Previous
Next ❯

Citations

Jul 9, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Roshal R PatelJames W Welsh

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.