PMID: 9552756Apr 29, 1998Paper

Low-dose retinoid therapy for chemoprophylaxis of skin cancer in renal transplant recipients

Journal of the European Academy of Dermatology and Venereology : JEADV
G E GibsonG M Murphy

Abstract

Renal transplant recipients have an increased incidence of skin cancers, which may be multiple and aggressive. The purpose of this study was to examine the chemoprophylactic effects of low-dose etretinate (0.3 mg/kg/day) on skin cancer development in renal transplant recipients and to monitor retinoid toxic effects at this dose. All skin lesions were counted and photographed prior to therapy with etretinate. Patients were assessed at monthly intervals for new skin lesions and for retinoid toxicity. Eleven renal transplant recipients participated. There was a significant reduction in the number of skin cancers which occurred during etretinate therapy compared with pre-treatment for 3 and 6 months of treatment, and a trend towards fewer skin cancers in the 12 and 18 month treatment periods. Side-effects were well-tolerated and no significant biochemical effects were observed. Low dose etretinate is safe, well-tolerated and partially effective in chemoprophylaxis of skin cancer in renal transplant recipients.

Citations

Jan 17, 2004·Journal of the American Academy of Dermatology·Jürgen V SmitElke M G J de Jong
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Y G L De GraafJ N Bouwes Bavinck
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Juan-Carlos MartinezUNKNOWN International Transplant-Skin Cancer Collaborative
Sep 24, 2004·Dermatologic Therapy·William G Stebbins, Mark G Lebwohl
Jun 1, 2000·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P Blackstien-HirschP Norton
Jan 22, 2003·The Cochrane Database of Systematic Reviews·P G GibsonE H Walters
Jan 22, 2003·The Cochrane Database of Systematic Reviews·H Powell, P G Gibson

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