Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone

Anesthesia and Analgesia
Hiroshi KitahataShuzo Oshita

Abstract

We investigated in rabbits whether sevoflurane enhances late cardioprotection induced by geranylgeranylacetone (GGA), a gastric antiulcer drug. S(+)-ketamine and xylazine-anesthetized rabbits were assigned to one of seven experimental groups: a control (vehicle only) group, a GGA group, a sevoflurane group, a GGA+sevoflurane group, a sodium 5-hydroxydecanoate (5HD) group, a GGA + 5HD group, and a heat stress group. All rabbits were subjected to 30 min of coronary artery occlusion followed by 3 h of reperfusion. Rabbits were pretreated with IV vehicle, GGA (10 mg/kg), or heat stress (42 degrees C for 15 min) 24 h before coronary occlusion. Sevoflurane (0.5 minimum alveolar concentration) or 5HD (5 mg/kg) were administered before myocardial ischemia. Myocardial infarct size and the area at risk for ischemia were measured, and heat shock protein (Hsp) 70 levels in each experimental group were determined. Compared with vehicle only, GGA significantly reduced the size of myocardial infarction in relation to the area at risk (39 +/- 10% vs 59 +/- 9%, P < 0.02). Sevoflurane enhanced the GGA-induced cardioprotection (23 +/- 17%, P < 0.05 vs GGA). The cardioprotective effect of GGA was abolished by administration of 5HD (56 +/- 15%, P <...Continue Reading

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Citations

Mar 4, 2014·Life Sciences·Yasuo M TsutsumiKatsuya Tanaka
Apr 16, 2018·Cardiovascular Therapeutics·Shengqiang ZengYanqing Wu
Apr 17, 2009·Current Opinion in Anaesthesiology·Stefan G De HertWolfgang S Schlack
Nov 30, 2019·Biochemical and Biophysical Research Communications·Anita LuethyJoseph F Cotten
Jul 9, 2009·Current Opinion in Anaesthesiology

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