Low-dose, simple, and fast grating-based X-ray phase-contrast imaging.

Proceedings of the National Academy of Sciences of the United States of America
Peiping ZhuMarco Stampanoni

Abstract

Phase sensitive X-ray imaging methods can provide substantially increased contrast over conventional absorption-based imaging and therefore new and otherwise inaccessible information. The use of gratings as optical elements in hard X-ray phase imaging overcomes some of the problems that have impaired the wider use of phase contrast in X-ray radiography and tomography. So far, to separate the phase information from other contributions detected with a grating interferometer, a phase-stepping approach has been considered, which implies the acquisition of multiple radiographic projections. Here we present an innovative, highly sensitive X-ray tomographic phase-contrast imaging approach based on grating interferometry, which extracts the phase-contrast signal without the need of phase stepping. Compared to the existing phase-stepping approach, the main advantages of this new method dubbed "reverse projection" are not only the significantly reduced delivered dose, without the degradation of the image quality, but also the much higher efficiency. The new technique sets the prerequisites for future fast and low-dose phase-contrast imaging methods, fundamental for imaging biological specimens and in vivo studies.

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Citations

Jun 1, 2011·Analytical and Bioanalytical Chemistry·Kai ZhangZiyu Wu
Jun 15, 2011·Analytical and Bioanalytical Chemistry·Xin GeZiyu Wu
May 2, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·M MarinescuM Wiart
Jun 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·I ZanetteT Weitkamp
Oct 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yunzhe ZhaoAlberto Bravin
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Peter R T MunroAlessandro Olivo
Aug 16, 2011·Physics in Medicine and Biology·Dan StutmanClifton O Bingham
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Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Houxun MiaoHan Wen
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Jun 3, 2014·Biomedical Engineering Online·Lu ZhangShuqian Luo
Jul 6, 2014·Medical Physics·C K HagenA Olivo
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Elena EgglFranz Pfeiffer
Oct 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Irene ZanetteFranz Pfeiffer
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Feb 23, 2012·Physics in Medicine and Biology·Jian-Zhong HuHong-Bin Lu
May 4, 2016·Optics Express·Panyun LiPeiping Zhu

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