Abstract
Although considerable work has focused on understanding the processes of direct tissue injury mediated by the chemical warfare vesicant, sulfur mustard (2,2'-bis-chloroethyl sulfide; SM), relatively little is known regarding the mechanisms of secondary injury caused potentially by the acute inflammatory response that follows SM exposure. Polymorphonuclear leukocytes (PMNs) play a central role in the initiation and propagation of inflammatory responses that, in some cases, result in autoimmune tissue damage. The potential for PMN-derived tissue damage following SM exposure may, in part, account for the protracted progression of the injury before it resolves. The current study was undertaken to evaluate the priming, oxidative function, and viability of PMN following exposure to low doses of SM such as those that might remain in tissues as a result of topical exposure. Our results demonstrate that doses of SM ranging from 25 to 100 microM primed PMN for oxidative burst in response to activation by fMLP, and that doses of SM ranging from 50 to 100 microM induced PMN apoptosis. Understanding the mechanisms through which SM directly affects PMN activation and apoptosis will be of critical value in developing novel treatments for infl...Continue Reading
References
Jan 1, 1989·The Journal of Clinical Investigation·J R ForehandR B Johnston
Aug 15, 1984·Analytical Biochemistry·P A Hyslop, L A Sklar
Dec 1, 1984·The Journal of Experimental Medicine·L A GuthrieR B Johnston
May 1, 1993·Infection and Immunity·C YamamotoY Mizuguchi
May 1, 1995·Journal of the American Academy of Dermatology·K J SmithF R Sidell
May 1, 1993·Archives of Biochemistry and Biophysics·J A Royall, H Ischiropoulos
Jun 1, 1996·Inflammation·J TsurutaP Mounts
Dec 1, 1996·Toxicology and Applied Pharmacology·M I DabrowskaD B Hinshaw
Apr 1, 1997·Inflammation·F TanakaD L Kreutzer
May 15, 1997·Biochemical Pharmacology·C B MillardC A Broomfield
Oct 23, 1997·Journal of Leukocyte Biology·J F SweeneyD B Hinshaw
Apr 16, 1998·The Journal of Surgical Research·J F SweeneyD B Hinshaw
May 5, 1998·Chemico-biological Interactions·G H HurS Shin
Jul 17, 1998·The Journal of Investigative Dermatology·D S RosenthalM E Smulson
Apr 2, 1999·Toxicology and Applied Pharmacology·D B HinshawM I Dabrowska
Jun 29, 2001·Journal of Applied Toxicology : JAT·M C BabinR P Casillas
Jun 29, 2001·Journal of Applied Toxicology : JAT·K M RickettsR P Casillas
Apr 24, 2002·Antioxidants & Redox Signaling·Steve D SwainMark T Quinn
Jan 1, 2003·Toxicology Mechanisms and Methods·Thomas P Logan, David A Sartori
Citations
Mar 24, 2004·International Immunopharmacology·Ashley K VavraJonathan M Levitt
Mar 26, 2014·Experimental and Molecular Pathology·Laurie B JosephJeffrey D Laskin
Nov 1, 2011·Toxicology and Applied Pharmacology·Hwa-Yong HamDong-Keun Song
Nov 9, 2010·Peptides·Yonatan SchussheimUri Wormser
May 29, 2007·Burns : Journal of the International Society for Burn Injuries·Guang-Qing Wang, Zhao-Fan Xia
Mar 19, 2014·Toxicology·Anil K JainRajesh Agarwal
Apr 11, 2014·BioMed Research International·Lei HaoLei Liu
Aug 4, 2016·Journal of Receptor and Signal Transduction Research·Mohammad Reza NouraniAbbas Ali Imani Fooladi
Sep 4, 2018·Interdisciplinary Toxicology·Alireza ShahriaryHossein Rahmani