Low-dose sulfur mustard primes oxidative function and induces apoptosis in human polymorphonuclear leukocytes

International Immunopharmacology
Jonathan M LevittJohn F Sweeney

Abstract

Although considerable work has focused on understanding the processes of direct tissue injury mediated by the chemical warfare vesicant, sulfur mustard (2,2'-bis-chloroethyl sulfide; SM), relatively little is known regarding the mechanisms of secondary injury caused potentially by the acute inflammatory response that follows SM exposure. Polymorphonuclear leukocytes (PMNs) play a central role in the initiation and propagation of inflammatory responses that, in some cases, result in autoimmune tissue damage. The potential for PMN-derived tissue damage following SM exposure may, in part, account for the protracted progression of the injury before it resolves. The current study was undertaken to evaluate the priming, oxidative function, and viability of PMN following exposure to low doses of SM such as those that might remain in tissues as a result of topical exposure. Our results demonstrate that doses of SM ranging from 25 to 100 microM primed PMN for oxidative burst in response to activation by fMLP, and that doses of SM ranging from 50 to 100 microM induced PMN apoptosis. Understanding the mechanisms through which SM directly affects PMN activation and apoptosis will be of critical value in developing novel treatments for infl...Continue Reading

References

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Citations

Mar 24, 2004·International Immunopharmacology·Ashley K VavraJonathan M Levitt
Mar 26, 2014·Experimental and Molecular Pathology·Laurie B JosephJeffrey D Laskin
May 29, 2007·Burns : Journal of the International Society for Burn Injuries·Guang-Qing Wang, Zhao-Fan Xia
Mar 19, 2014·Toxicology·Anil K JainRajesh Agarwal
Apr 11, 2014·BioMed Research International·Lei HaoLei Liu
Aug 4, 2016·Journal of Receptor and Signal Transduction Research·Mohammad Reza NouraniAbbas Ali Imani Fooladi
Sep 4, 2018·Interdisciplinary Toxicology·Alireza ShahriaryHossein Rahmani

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