Sep 25, 2007

Low-dose tenecteplase during cardiopulmonary resuscitation due to massive pulmonary embolism: a case report and review of previously reported cases

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
David Václav Fred HeferHassan Khouli

Abstract

The case of a 29 year-old man who suffered a cardiac arrest due to a massive pulmonary embolism while he was undergoing surgical repair of a complex tibial plateau fracture is presented. After 70 min of unsuccessful cardiopulmonary resuscitation a bolus of 20 mg tenecteplase was given, with a return of spontaneous circulation 2 min after administration of the drug. Pulmonary embolism was subsequently demonstrated on a pulmonary angiogram. To our knowledge this is the first report to show that the use of a low dose of tenecteplase might be useful to achieve the return of spontaneous circulation in the resuscitation of patients with cardiac arrest secondary to massive pulmonary embolism. Previously reported cases are reviewed.

Mentioned in this Paper

Pulmonary Embolism
Tibial Fractures
Fatal Outcome
Basic Cardiac Life Support
Respiratory Failure
Entire Tibial Plateau
Actilyse
Injuries, Surgical
Blood Circulation
Cardiopulmonary

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