Low-Dose Testosterone and Evoked Resistance Exercise after Spinal Cord Injury on Cardio-Metabolic Risk Factors: An Open-Label Randomized Clinical Trial

Journal of Neurotrauma
Ashraf S GorgeyRobert A Adler

Abstract

The purpose of the work is to investigate the effects of low-dose testosterone replacement therapy (TRT) and evoked resistance training (RT) on body composition and metabolic variables after spinal cord injury (SCI). Twenty-two individuals with chronic motor complete SCI (ages 18-50 years) were randomly assigned to either TRT+RT (n = 11) or TRT (n = 11) for 16 weeks following a 4 -week delayed entry period. TRT+RT men underwent twice weekly progressive RT using electrical stimulation with ankle weights. TRT was administered via testosterone patches (2-6 mg/day). Body composition was tested using anthropometrics, dual energy x-ray absorptiometry, and magnetic resonance imaging. After an overnight fast, basal metabolic rate (BMR), lipid panel, serum testosterone, adiponectin, inflammatory and anabolic biomarkers (insulin-like growth factor-1 and insulin-like growth factor-binding protein 3 [IGFBP-3]), glucose effectiveness (Sg), and insulin sensitivity (Si) were measured. Total body lean mass (LM; 2.7 kg, p < 0.0001), whole muscle (p < 0.0001), and whole muscle knee extensor cross-sectional areas (CSAs; p < 0.0001) increased in the TRT+RT group, with no changes in the TRT group. Visceral adiposity decreased (p = 0.049) in the TRT...Continue Reading

References

Jan 1, 1995·Pediatric Radiology·V M KrissW J McRoberts
Jul 4, 1996·The New England Journal of Medicine·S BhasinR Casaburi
Dec 1, 1996·Journal of Applied Physiology·R RossP Shragge
Apr 20, 1999·JAMA : the Journal of the American Medical Association·A StrawfordM K Hellerstein
Sep 14, 1999·European Journal of Applied Physiology and Occupational Physiology·G A DudleyD F Apple
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Apr 6, 2000·Journal of Applied Physiology·A M SpungenW A Bauman
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·S M HarmanUNKNOWN Baltimore Longitudinal Study of Aging
Apr 3, 2001·Medicine and Science in Sports and Exercise·S E BorstM L Pollock
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M KjaerH Galbo
May 25, 2002·Journal of the American Geriatrics Society·Stephen E BorstRandy W Braith
Jan 24, 2003·The American Journal of Clinical Nutrition·Andrea C BuchholzPaul B Pencharz
May 6, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Bradley C NindlMichael Germain
Jun 15, 2005·Archives of Physical Medicine and Rehabilitation·Patricia J MannsDaniel P Williams
Oct 11, 2005·Archives of Physical Medicine and Rehabilitation·Yen-Ho WangTzung-Dau Wang
May 18, 2006·The Journal of Clinical Endocrinology and Metabolism·Indrani Sinha-HikimShalender Bhasin
Jun 5, 2007·Physical Medicine and Rehabilitation Clinics of North America·David R Gater
Apr 29, 2008·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·L GriffinJ L Ivy
Aug 22, 2008·American Journal of Physical Medicine & Rehabilitation·Mary J ClarkMichael E Acuff
Sep 28, 2010·Metabolism: Clinical and Experimental·Ashraf S GorgeyDavid R Gater
Feb 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ashraf S Gorgey, David R Gater
Jun 11, 2011·Medicine and Science in Sports and Exercise·Ashraf S GorgeyDavid R Gater
Jul 1, 2011·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W A BaumanA M Spungen
Aug 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Andre B AraujoGary A Wittert
Sep 29, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·I IsmailN A Johnson
Apr 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Molly M ShoresAlvin M Matsumoto
Oct 17, 2012·PloS One·Joshua F YarrowStephen E Borst
May 21, 2013·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Ashraf S GorgeyDavid R Gater
Jul 3, 2013·Archives of Physical Medicine and Rehabilitation·Terence E RyanKevin K McCully
Oct 5, 2013·The Journal of Spinal Cord Medicine·William A BaumanAnn M Spungen
Jan 1, 2014·Journal of Neurotrauma·Joshua F YarrowStephen E Borst
Jul 9, 2014·The Journal of Spinal Cord Medicine·Ashraf S GorgeyDavid R Gater
May 12, 2015·JAMA Internal Medicine·J Bradley LaytonM Alan Brookhart
Jun 7, 2015·Archives of Physical Medicine and Rehabilitation·Ashraf S GorgeyDavid R Gater

❮ Previous
Next ❯

Citations

Jan 31, 2020·Neural Regeneration Research·Subhalakshmi ChandrasekaranAshraf S Gorgey
Jan 15, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M E HolmanA S Gorgey
Nov 17, 2020·Topics in Spinal Cord Injury Rehabilitation·Michael StillmanDavid R Gater
Apr 6, 2021·Topics in Spinal Cord Injury Rehabilitation·Gary J FarkasDavid R Gater
Apr 6, 2021·Topics in Spinal Cord Injury Rehabilitation·Gary J FarkasDavid R Gater
Apr 6, 2021·Topics in Spinal Cord Injury Rehabilitation·David W McMillanDavid R Gater
Apr 24, 2021·European Journal of Applied Physiology·Jacob A GoldsmithAshraf S Gorgey
Aug 31, 2021·Current Opinion in Pharmacology·Dana M OtzelJoshua F Yarrow

❮ Previous
Next ❯

Methods Mentioned

BETA
testosterone replacement therapy
enzyme-linked immunosorbent assay
ELISA

Clinical Trials Mentioned

NCT01652040

Software Mentioned

Nutrition Data System for Research
Win
MINMOD
Vessel
Lunar
SPSS

Related Concepts

Related Feeds

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.