PMID: 9557925Apr 29, 1998Paper

Low-dose transdermal scopolamine decreases blood pressure in mild essential hypertension

Journal of Hypertension
R K VesalainenD L Eckberg

Abstract

Increasing cardiovascular parasympathetic nervous activity could have antihypertensive effects. Low-dose transdermal scopolamine increases vagal-cardiac modulation of sinus node and baroreflex sensitivity in healthy subjects and in cardiac patients. To study the short-term effects of transdermal scopolamine on blood pressure and cardiovascular autonomic control in patients with mild essential hypertension. A randomized, double-blind, placebo-controlled crossover trial with 12 untreated middle-aged [aged 39+/-5 years (mean+/-SD)] patients with mild essential hypertension. We recorded the electrocardiogram, auscultatory sphygmomanometric and continuous photoplethysmographic finger arterial pressure, and spirometry signals with patients supine and 70 degrees tilted during controlled (0.25 Hz) breathing. Cardiovascular autonomic regulation was analyzed with power spectrum analysis of R-R interval and arterial pressure variability and a spontaneous sequence method for baroreflex sensitivity. In addition, a deep-breathing test was performed to assess maximal breathing-related sinus arrhythmia. Transdermal scopolamine treatment significantly decreased blood pressure both when patients lay supine and when they were in the 70 degrees ti...Continue Reading

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Citations

Aug 4, 2001·Autonomic Neuroscience : Basic & Clinical·H BettermannH C Kümmell
Oct 27, 2001·Journal of Autonomic Pharmacology·J PenttiläH Scheinin
Dec 8, 2016·Complementary Medicine Research·Claudia Rother, Martin Schnelle

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