Low doses of dexamethasone constantly delivered by autologous erythrocytes slow the progression of lung disease in cystic fibrosis patients

Blood Cells, Molecules & Diseases
Luigia RossiMauro Magnani

Abstract

To evaluate the safety and efficacy of the administration of low doses of glucocorticoids in patients with cystic fibrosis (CF) by using autologous erythrocytes loaded with dexamethasone 21-phosphate. Nine consecutive CF patients (patients nos. 1-9) received autologous erythrocytes loaded with increasing amounts of dexamethasone 21-phosphate to obtain a slow delivery of dexamethasone in circulation. The appearance of possible adverse effects, the reproducibility of the procedure, and the dexamethasone pharmacokinetics were evaluated. Subsequently, patient no. 9 and eight additional patients (patient nos. 10-17) received dexamethasone 21-phosphate-loaded erythrocytes at 1-month intervals to evaluate the efficacy of continuous release in circulation of low doses of dexamethasone. Erythrocytes from CF patients can be processed to be loaded with increasing dexamethasone 21-P concentrations. Once reinfused in respective donors, a slow and prolonged delivery of dexamethasone in the blood stream was measured up to 28 days. Repeated administrations of drug-loaded erythrocytes at 4-week intervals for 15 months showed that very low doses of glucocorticoids provide significant improvement in FEV1 values and significant reduction of infect...Continue Reading

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A De FloraU Benatti
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G M IhlerF W Schnure
Oct 1, 1993·The American Review of Respiratory Disease·M W KonstanJ B Hilliard
Jun 1, 1993·Archives of Disease in Childhood·J F Price, P Greally
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·P B DavisM W Konstan
Apr 25, 2000·Respiration; International Review of Thoracic Diseases·J Zielenski
Mar 30, 2001·Biotechnology and Applied Biochemistry·L RossiM Magnani
Apr 23, 2002·Pharmacogenomics·Federica SangiuoloGiuseppe Novelli

❮ Previous
Next ❯

Citations

Mar 17, 2006·Journal of Pediatric Gastroenterology and Nutrition·Massimo CastroMauro Magnani
Oct 8, 2004·Pharmacogenomics·Federica SangiuoloGiuseppe Novelli
Jul 27, 2012·Therapeutic Delivery·Carmen Gutiérrez MillánJosé M Lanao
Feb 20, 2014·Expert Opinion on Drug Delivery·Mauro Magnani, Luigia Rossi
Jan 25, 2014·Expert Opinion on Drug Delivery·Abdolhossein ZarrinMehrdad Hamidi
Mar 3, 2010·Expert Opinion on Drug Delivery·Vladimir R Muzykantov
May 19, 2009·Expert Opinion on Pharmacotherapy·Fabrizio BossaVito Annese
Mar 4, 2009·Journal of Drug Targeting·Alessandra FraternaleMauro Magnani
Nov 22, 2005·Expert Opinion on Drug Delivery·Luiga RossiMauro Magnani
Jul 3, 2007·Expert Opinion on Emerging Drugs·Pamela L Zeitlin
Apr 13, 2005·Journal of Drug Targeting·Luigia RossiMauro Magnani
Nov 2, 2005·Rapid Communications in Mass Spectrometry : RCM·Andrea ArmirottiGianluca Damonte
Nov 28, 2012·Advanced Healthcare Materials·Che-Ming J HuLiangfang Zhang
Aug 5, 2006·Journal of Pharmaceutical and Biomedical Analysis·Gianluca DamonteUmberto Benatti
Jul 15, 2005·Molecular & Cellular Proteomics : MCP·Noura BensalemAleksander Edelman
Jun 3, 2005·The American Journal of Gastroenterology·Vito AnneseMauro Magnani
Oct 16, 2008·The American Journal of Gastroenterology·Michael F Picco
Jul 19, 2011·IUBMB Life·Sara BiagiottiMauro Magnani
Mar 22, 2020·Pharmaceutics·Larisa KolevaElena Sinauridze
Oct 6, 2020·Frontiers in Physiology·Luigia RossiMauro Magnani
Mar 22, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Luigia RossiMauro Magnani
Jan 25, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Francesca PierigèMauro Magnani
Jul 7, 2017·Orphanet Journal of Rare Diseases·Michele MenottaMauro Magnani
Mar 28, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Majid Zaki-DizajiAsghar Aghamohammadi
Jul 27, 2017·Molecular and Cellular Biochemistry·Michele MenottaMauro Magnani
Aug 28, 2020·Expert Opinion on Drug Delivery·Claire H MastersonJohn G Laffey
Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Laura ChiarantiniLuisa Tondelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here