Low doses of gamma irradiation potentially modifies immunosuppressive tumor microenvironment by retuning tumor-associated macrophages: lesson from insulinoma

Carcinogenesis
Hridayesh PrakashLiudmila Umansky

Abstract

Tumor infiltrating iNOS+ macrophages under the influence of immunosuppressive tumor microenvironment gets polarized to tumor-promoting and immunosuppressive macrophages, known as tumor-associated macrophages (TAM). Their recruitment and increased density in the plethora of tumors has been associated with poor prognosis in cancer patients. Therefore, retuning of TAM to M1 phenotype would be a key for effective immunotherapy. Radiotherapy has been a potential non-invasive strategy to improve cancer immunotherapy and tumor immune rejection. Irradiation of late-stage tumor-bearing Rip1-Tag5 mice twice with 2 Gy dose resulted in profound changes in the inflammatory tumor micromilieu, characterized by induction of M1-associated effecter cytokines as well as reduction in protumorigenic and M2-associated effecter cytokines. Similarly, in vitro irradiation of macrophages with 2 Gy dose-induced expression of iNOS, NO, NFκBpp65, pSTAT3 and proinflammatory cytokines secretion while downregulating p38MAPK which are involved in iNOS translation and acquisition of an M1-like phenotype. Enhancement of various M2 effecter cytokines and angiogenic reprogramming in iNOs+ macrophage depleted tumors and their subsequent reduction by 2 Gy dose in Ri...Continue Reading

References

Sep 29, 2001·Nature Immunology·C Bogdan
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Jun 23, 2004·Clinical Colorectal Cancer·Leo ShunyakovAlok A Khorana
Apr 25, 2006·The Journal of Surgical Research·David A EdelmanChristopher Steffes
Jul 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhengfan JiangBruce Beutler
Apr 11, 2007·Cellular Immunology·Hongwei RenToru Abo
Apr 27, 2007·The Journal of Investigative Dermatology·Silvina GazzanigaRosa Wainstok
Jun 28, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M ZeydaT M Stulnig
Oct 5, 2007·Critical Reviews in Oncology/hematology·Paola AllavenaAlberto Mantovani
Mar 21, 2008·Blood·Pawel MuranskiNicholas P Restifo
May 2, 2008·Cancer Letters·Antonio SicaAlberto Mantovani
Mar 14, 2009·Nature Reviews. Immunology·Jeffrey W Pollard
Aug 8, 2009·European Journal of Immunology·Eva MonsalveMaría José M Díaz-Guerra
Feb 13, 2010·Annual Review of Physiology·Jerrold M Olefsky, Christopher K Glass
Apr 21, 2010·Seminars in Immunology·Yuting MaLaurence Zitvogel
Jun 2, 2010·Biochemical and Biophysical Research Communications·Suk Chul ShinHee Sun Kim
Jun 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Graziella SolinasPaola Allavena
Jun 24, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei ZhangZhao-You Tang
Nov 29, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhen HuangJunfeng Zhang
Mar 1, 2012·Journal of Radiation Research·Ki Moon SeongYoung-Woo Jin
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hongwei QinEtty N Benveniste
Mar 23, 2012·Nature Reviews. Immunology·Dmitry I GabrilovichVincenzo Bronte
Jan 11, 2013·Dose-response : a Publication of International Hormesis Society·Ewa M NowosielskaMarek K Janiak

❮ Previous
Next ❯

Citations

Dec 19, 2018·Cancers·Shang-Jui Wang, Bruce Haffty
Jun 23, 2019·Cancers·Jihane BoustaniCéline Mirjolet
Feb 1, 2018·Therapeutic Advances in Medical Oncology·Thomas WalleFernando Lecanda
Oct 1, 2020·Clinical & Translational Immunology·Synat KeamAlistair M Cook
Jun 29, 2018·Cell Death & Disease·Géraldine GenardCarine Michiels
Jul 9, 2020·International Journal of Molecular Sciences·Camille HuartAnne-Catherine Wéra
Jun 27, 2019·Journal for Immunotherapy of Cancer·Mathieu GrapinCéline Mirjolet
May 11, 2020·British Journal of Clinical Pharmacology·Valentí GómezTony Ng
Jul 28, 2020·Cancers·Anna Maria MalfitanoGiuseppe Portella
Jul 3, 2020·Frontiers in Oncology·Jiarui ChenConghua Xie
Jun 24, 2017·Frontiers in Immunology·Sebastian Diegeler, Christine E Hellweg
Mar 20, 2018·Cancer Growth and Metastasis·Kimberly M ArnoldJennifer Sims-Mourtada
Aug 1, 2019·The Lancet Oncology·Sana D Karam, David Raben
Nov 13, 2020·Frontiers in Pharmacology·Devinder ToorHridayesh Prakash
Nov 18, 2020·Journal of Cellular Physiology·Yibing ChenZhengzhi Zou
Jul 20, 2020·International Immunopharmacology·Milad AshrafizadehMasoud Najafi
Apr 4, 2021·International Journal of Molecular Sciences·Galina F MedvedevaMarina S Dukhinova
Mar 30, 2021·World Journal of Gastroenterology : WJG·Byung Min Lee, Jinsil Seong
Apr 19, 2021·International Journal of Radiation Oncology, Biology, Physics·Eva ReijmenCleo Goyvaerts
Aug 30, 2019·International Immunopharmacology·Keywan MortezaeeBagher Farhood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.