Low doses of mercuric chloride cause the main features of anti-nucleolar autoimmunity in female outbred CFW mice

Toxicology and Industrial Health
Alla S ArefievaMarina S Krasilshchikova

Abstract

The growth of the influence of anthropogenic factors aimed on the improvement of human life has its side effect, for example, living organisms receive increasing exposure to toxic mercuric compounds. Experimental data show that mercury (Hg) salts are able to induce systemic autoimmunity in rodents. This Hg-induced autoimmune process (HgIA) is characterized by T cell-dependent polyclonal activation of B lymphocytes, increased level of serum immunoglobulin G1 (IgG1) and immunoglobulin E (IgE), production of antinucleolar autoantibodies (ANoA), and immune complex deposition in multiple organs. HgIA in mice is used as a model of human systemic autoimmune disorders. However, the dose of mercuric chloride (HgCl2) usually used in laboratory mice to induce HgIA is above the allowable limit for everyday levels of Hg exposure in humans. So, we decided to determine the lowest dose of HgCl2 that is able to trigger autoimmunity in outbred Carworth Farms Swiss Webster (CFW) mice not genetically prone to HgIA development. The lowest dose (50 µg/kg body weight (b.w.)/week) was chosen to match the World Health Organization provisional weekly tolerable intake of total Hg for humans. We also tested HgCl2 at 500 and 1500 µg/kg b.w./week (6.5- and ...Continue Reading

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Citations

Jan 8, 2016·International Journal of Environmental Research and Public Health·Deniz YeterHo-Chang Kuo
May 26, 2018·Journal of Fungi·Alexander Batista-DuharteIracilda Zeppone Carlos
Dec 29, 2020·Toxicology and Applied Pharmacology·Mehdi AmirhosseiniSaid Havarinasab

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

STATISTICA

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