Abstract
Syndromic sexually transmitted infection (STI) treatment remains a cost-saving HIV prevention intervention in many countries in Africa. We estimate the effectiveness of syndromic treatment for curable STIs in rural KwaZulu-Natal, South Africa, and the trend in STI prevalences before and after the introduction of syndromic treatment in 1995. Data were available from various clinical studies, surveys of public and private health providers, the general population and women attending antenatal, family planning and child immunisation clinics in rural northern KwaZulu-Natal between 1987 and 2004. Overall effectiveness was defined as the estimated proportion of the annual number of symptomatic curable STI episodes cured by syndromic treatment based on separate estimates for six curable STI aetiologies by gender. Median overall effectiveness was 13.1% (95% CI 8.9 to 17.8%) of symptomatic curable STI episodes cured. Effectiveness increased to 25.0% (95% CI 17.3 to 33.8%), 47.6% (95% CI 44.5 to 50.8%) or 14.3% (95% CI 9.9 to 19.4%) if 100% treatment seeking, 100% correct treatment provision or 100% cure were assumed, respectively. Time-trends were difficult to assess formally but there was little evidence of decreasing STI prevalences. I...Continue Reading
References
Aug 1, 1989·Genitourinary Medicine·N O'FarrellJ van den Ende
Jan 23, 1998·Sexually Transmitted Diseases·D WilkinsonS S Karim
May 16, 1998·Genitourinary Medicine·D WilkinsonA W Sturm
Aug 14, 1998·American Journal of Public Health·A W SturmC Connolly
Oct 9, 1998·International Journal of STD & AIDS·M ColvinN Ntuli
Dec 24, 1998·AIDS·A HarrisonS A Karim
Jun 11, 1999·International Journal of STD & AIDS·A M ConnollyS S Karim
Feb 28, 2001·Sexually Transmitted Infections·H GrosskurthD Mabey
Dec 12, 2001·Tropical Medicine & International Health : TM & IH·A BuvéR J Hayes
Jan 7, 2003·Sexually Transmitted Diseases·Prashini MoodleyA Willem Sturm
Mar 5, 2003·Sexually Transmitted Diseases·Prashini MoodleyA Willem Sturm
Mar 10, 2004·International Journal of STD & AIDS·P D J SturmA Willem Sturm
Sep 15, 2004·International Journal of Antimicrobial Agents·Prashini Moodley, A W Sturm
Nov 19, 2004·Tropical Medicine & International Health : TM & IH·Landon MyerDavid Wilkinson
Jan 1, 2005·The Journal of Infectious Diseases·E L KorenrompR J Hayes
Aug 3, 2005·Sexually Transmitted Infections·L F JohnsonR E Dorrington
Mar 31, 2006·Sexually Transmitted Diseases·Prashini MoodleyA Willem Sturm
Jun 26, 2007·AIDS·Tanya WelzMarie-Louise Newell
Jan 8, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Richard G WhiteRichard J Hayes
Citations
Feb 9, 2011·Epidemiology and Infection·L F JohnsonD Bradshaw
Apr 23, 2013·Sexually Transmitted Infections·Sarita Naidoo, Handan Wand
Dec 16, 2009·BMC Public Health·Omar GalárragaStefano M Bertozzi
Jul 17, 2010·PloS One·Carol S CamlinRachel C Snow
Jul 30, 2011·PloS One·Jan A C HontelezMark N Lurie
Apr 1, 2014·BMC Infectious Diseases·Mathys J RedelinghuysMarleen M Kock
Dec 15, 2010·Sexual & Reproductive Healthcare : Official Journal of the Swedish Association of Midwives·Leigh F JohnsonDavid J Coetzee
Sep 21, 2011·Journal of Internal Medicine·B E NicholsD A M C van de Vijver
Oct 6, 2016·PloS One·Charifa ZemouriNathalie Broutet
Apr 17, 2016·Sexually Transmitted Infections·Nigel J GarrettAdrian Mindel
Nov 19, 2011·International Journal of STD & AIDS·E PultorakS D Mehta
Jun 15, 2010·Current Opinion in HIV and AIDS·Elizabeth HamlynSarah Fidler
Feb 25, 2020·International Journal of STD & AIDS·Andrew Medina-MarinoJeffrey D Klausner
Aug 12, 2017·International Journal of STD & AIDS·Maanda MudauAndrew Medina-Marino
Jun 10, 2020·PloS One·Shu-Xia ChangYu-Mao Cai
Apr 21, 2012·The Journal of Infectious Diseases·Koleka MlisanaSalim S Abdool Karim
Jun 5, 2018·Infectious Diseases in Obstetrics and Gynecology·E MorikawaA Medina-Marino
Apr 25, 2018·PloS One·Nigel J GarrettAdrian Mindel
Apr 4, 2017·PloS One·Naomi Lince-DerocheKelly Blanchard
May 15, 2020·International Journal of STD & AIDS·Pooja ChitneniUNKNOWN AYAZAZI Research Team
Sep 2, 2020·Antimicrobial Agents and Chemotherapy·Liteboho D MadunaRemco P H Peters
Mar 16, 2021·The Cochrane Database of Systematic Reviews·Jael ObieroCharles S Wiysonge
Apr 17, 2021·Sexually Transmitted Diseases·Victor OmolloJared M Baeten