Low Endogenous Secretory Receptor for Advanced Glycation End-Products Levels Are Associated With Inflammation and Carotid Atherosclerosis in Prediabetes

The Journal of Clinical Endocrinology and Metabolism
Antonino Di PinoAgata Maria Rabuazzo

Abstract

Prediabetes is associated with atherosclerotic vascular damage. We investigated the correlation of endogenous secretory receptor for advanced glycation end-products (esRAGE), total soluble RAGE (sRAGE) and markers of inflammation, with early cardiovascular disease in subjects with prediabetes. We particularly focused on individuals with prediabetes identified only by glycated hemoglobin A1c (HbA1c) (5.7–6.4%) who had normal fasting glucose and were normotolerant after oral glucose tolerance test. This was a cross-sectional study. The study was conducted in the Department of Clinical and Molecular Medicine, University of Catania, Italy. sRAGE, esRAGE, carboxymethyl-lysine, S100A12, HbA1c, fasting glycemia, oral glucose tolerance test, pulse wave velocity, and intima-media thickness were evaluated in subjects with prediabetes. Three hundred eighty subjects without previous history of diabetes were stratified into three groups: controls (n = 99), prediabetes (n = 220), and new-onset type 2 diabetes (n = 61). Subjects with prediabetes exhibited the following: lower esRAGE (0.29 ± 0.18 vs 0.45 ± 0.26 ng/mL; P < .05) and higher S100A12 levels than controls. RT-PCR analysis in mononuclear cells revealed that the mRNA expression level ...Continue Reading

References

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Citations

May 6, 2019·Expert Review of Molecular Diagnostics·Ju-Yang JungHyoun-Ah Kim
Oct 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Antonino Di PinoAgata Maria Rabuazzo
Feb 12, 2020·Journal of Clinical Medicine·Elena DozioMassimiliano Marco Corsi Romanelli
May 6, 2019·Endocrine Reviews·Antonino Di Pino, Ralph A DeFronzo
Apr 17, 2019·Acta Diabetologica·Enric SánchezUNKNOWN ILERVAS Project
Mar 14, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Christian J KonopkaLawrence W Dobrucki
Oct 7, 2020·International Journal of Molecular Sciences·Adriana Machado-LimaMarisa Passarelli
May 1, 2021·International Journal of Molecular Sciences·Yin LiangKen Takahashi
Mar 19, 2020·Current Vascular Pharmacology·Olga Lamacchia, Maria Rosaria Sorrentino
Sep 3, 2021·International Journal of Clinical Practice·Rumyana DimovaTsvetalina Tankova

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