Low endometrial beta-catenin and cadherins expression patterns are predictive for primary infertility and recurrent pregnancy loss

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Filippo BellatiDonatella Caserta

Abstract

Inadequate uterine receptivity is responsible for two-third of implanting failures. Aim of the study was to investigate the role of epithelial adherence and tight-junction molecules expressed by human endometrium in predicting womens' fertility outcome. A total of 76 consecutive women, including 24 fertile (G1), 40 primary infertile (G2), and 12 recurrent pregnancy loss (RPL, G3) women, who underwent diagnostic hysteroscopy plus endometrial biopsy between 2005 and 2016 at the Gynecology Division of Sant'Andrea Hospital, Sapienza University of Rome, in Italy, were retrospectively identified and included into the study. Endometrial biopsies were assessed for the immunohistochemical expression of beta-catenin (β-catenin), E-cadherin and K-cadherin biomarkers. Expression profiles were compared between the three groups of patients and were correlated with patients' fertility outcome. In infertile patients there was a significant lower endometrial expression of β-catenin (p = .001), E-cadherin (p = .001) and K-cadherin (p = .002), compared to the fertile ones. Furthermore, β-catenin and E-cadherin intensity gradients of expression at glandular level were found totally reversed in infertile patients. Significant lower expression level...Continue Reading

References

Mar 31, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S GetsiosC D MacCalman
Oct 24, 1998·Journal of Reproductive Immunology·C SimónA Pellicer
Apr 11, 2002·Nature Cell Biology·Colin Jamora, Elaine Fuchs
Jul 9, 2004·Reproductive Biology and Endocrinology : RB&E·John D Aplin, Susan J Kimber
Aug 15, 2006·Lancet·Raj Rai, Lesley Regan
Sep 20, 2006·Human Reproduction Update·Hanna Achache, Ariel Revel
Jun 19, 2007·Trends in Molecular Medicine·Kwang-Hyun BaekYong-Soo Kim
Nov 11, 2008·Fertility and Sterility·Maurizio MacalusoLori A Pollack
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Lawrence Shapiro, William I Weis
May 24, 2012·The EMBO Journal·Tomas ValentaKonrad Basler
Jun 12, 2012·Cell·Hans Clevers, Roel Nusse
Sep 29, 2012·Current Pharmaceutical Design·Andrey Voronkov, Stefan Krauss
Oct 26, 2012·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
Mar 23, 2013·Science·J D Berndt, R T Moon
Feb 12, 2017·The Journal of Endocrinology·Amanda L PattersonJose M Teixeira

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