Low-exposure cadmium is more toxic on osteoporotic rat femoral bone: mechanical, biochemical, and histopathological evaluation

Ecotoxicology and Environmental Safety
Ulku ComelekogluAysegul Turac

Abstract

This study aimed to investigate the effects of low-exposure Cd on normal and osteoporotic bone. For this purpose, 12-week-old Sprague-Dawley female rats were assigned randomly to a control group, a Cd group, and an ovariectomy (OVX)+Cd group. OVX+Cd rats underwent bilateral ovariectomy via ventral incision. Twelve weeks after ovariectomy, cadmium chloride (CdCl(2)) was given to rats (Cd and OVX+Cd groups) as intraperitoneal (ip) injection of 0.5mg/kg three times a week for 18 weeks and distilled water was given to control group via ip route for 18 weeks. Bone mineral density (BMD) was measured at mid-diaphysis femoral region by dual-energy X-ray absorbsiometry. Cross-sectional area of the femoral shaft was evaluated by computerized tomography. Biomechanical measurements were performed at the mid-diaphysis of the left femur. Collagen fibers were evaluated at light microscopic level. BMD, cortical thickness, cortical area, and femur length were not changed in Cd and OVX+Cd groups in comparision to controls. In the OVX+Cd group, strength, displacement, energy, stress, strain, and toughness were significantly lower than those of the control group. The Cd concentration of bone was significantly increased in the OVX+Cd group compared...Continue Reading

References

Jan 1, 1992·Archives of Toxicology·K OgoshiT Moriyama
Jun 1, 1986·Environmental Research·S KawanoK Tsujikawa
Jan 1, 1993·Archives of Toxicology·K Iwami, T Moriyama
Nov 17, 1998·Occupational and Environmental Medicine·L JärupC G Elinder
Mar 18, 2000·Toxicology Letters·M BerglundM Vahter
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hongfu WangGunnar F Nordberg
Sep 18, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Malgorzata M Brzóska, Janina Moniuszko-Jakoniuk
May 20, 2005·Archives of Toxicology·Małgorzata M BrzóskaJanina Moniuszko-Jakoniuk

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Citations

Jun 2, 2011·Archives of Environmental Contamination and Toxicology·Xiao ChenYunzhen Yu
Jun 10, 2011·Biological Trace Element Research·Xiao ChenShuzhu Gu
Sep 3, 2011·Acta Veterinaria Scandinavica·Monika MartiniakováRóbert Toman
Jun 19, 2008·Environmental Health Perspectives·Rudolph SchutteJan A Staessen
Jun 24, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Maria BodoLorella Marinucci
Apr 14, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Malgorzata M BrzóskaKatarzyna Majewska
Sep 1, 2009·Environmental Toxicology and Pharmacology·Xiao ChenChunlin Shao
Oct 4, 2014·Acta Veterinaria Scandinavica·Hana DuranovaRobert Toman
Mar 20, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Ivana ZofkováPetr Matucha
Sep 13, 2011·Experimental Biology and Medicine·Xiao ChenHanfang Xiao
Sep 7, 2018·Journal of Exposure Science & Environmental Epidemiology·Xiao ChenXiaoqiang Ding
May 7, 2020·Advanced Pharmaceutical Bulletin·Velid UnsalEngin Kölükçü
Nov 5, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mayra A Graniel-AmadorSergio Montes
Aug 3, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sana BoughammouraMartine Cohen Solal

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