Low expression levels of insulin-like growth factor binding protein-3 are correlated with poor prognosis for patients with hepatocellular carcinoma

Oncology Letters
Jinjin YanXinlong Wang

Abstract

Insulin-like growth factor binding protein-3 (IGFBP-3) has previously been identified as a putative tumor suppressor gene. The present study investigated the clinical and prognostic significance of IGFBP-3 expression levels in patients with hepatocellular carcinoma (HCC). Immunohistochemistry (IHC) probing for IGFBP-3 was performed on paraffin-embedded tissue samples obtained from 120 patients with HCC, including tissue samples from 120 primary cancer sites and 50 matched adjacent non-malignant sites. Receiver-operator curve (ROC) analysis was used to determine the cut-off scores for the presence of IGFBP-3-positive tumor cells and to estimate the survival time of the patients. The threshold for marking the positive expression of IGFBP-3 was 65%, based on the area under the ROC. Positive expression of IGFBP-3 was observed in 65/120 (54.2%) of the HCC tissues, and in 36/50 (72%) of the adjacent non-malignant liver tissues. Low levels of IGFBP-3 expression were correlated with tumor size (P=0.003), tumor multiplicity (P=0.044), node (P=0.008), metastasis (P=0.001) and clinical stage (P=0.001), as well as reduced survival time (P=0.015). Using univariate survival analysis, a significant direct correlation between high and low IGFB...Continue Reading

References

Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Jun 5, 2001·Apoptosis : an International Journal on Programmed Cell Death·A J Butt, A C Williams
Jun 22, 2005·Expert Review of Proteomics·Sherryline Jogie-BrahimYoungman Oh
Jun 25, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G VarottiA Pinna
Mar 3, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Mujde AkturkFusun Toruner
Jan 5, 2011·Biochemical and Biophysical Research Communications·Kei YoshinoJun-ichi Ogawa
Aug 3, 2011·Brain Research Bulletin·Zhenyu ZhaoYi-Cheng Lu
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
Mar 23, 2013·Journal of Gastroenterology and Hepatology·Dai Hoon HanKwang-Hyub Han
May 31, 2013·Journal of Gastroenterology·Hironori TanakaShuhei Nishiguchi
Jun 13, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eun Ju ChoHyo-Suk Lee
Mar 13, 2014·Genetics and Molecular Research : GMR·X P HuangY F Zhang
Apr 17, 2014·BioMed Research International·Sean C Taylor, Anton Posch
Jun 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Faruk TasDerya Duranyildiz
Sep 26, 2014·Journal of Cancer Therapy·Hanief Mohammad Shahjee, Nisan Bhattacharyya

❮ Previous
Next ❯

Citations

Apr 28, 2018·International Journal of Molecular Sciences·Agnieszka Adamek, Aldona Kasprzak
Apr 18, 2020·Molecular and Cellular Biochemistry·Moisés Martínez-CastilloGabriela Gutierrez-Reyes
Jun 21, 2019·Journal of Clinical Laboratory Analysis·Yu-Lei HouHui Chen
Mar 7, 2021·International Journal of Molecular Sciences·Mai-Huong Thi NgoYen-Hua Huang
Aug 5, 2021·Current Research in Toxicology·Olha V RudnytskaOleksandr Minchenko

❮ Previous
Next ❯

Software Mentioned

SPSS
Image lab

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.