Low expression of AIM2 combined with high expression of p‑STAT3 is associated with poor prognosis in hypopharyngeal squamous cell carcinoma

Oncology Reports
Zhen LiXiaoming Li

Abstract

Studies indicate that the AIM2 inflammasome plays an important role in tumor occurrence and development. The present study examined the prognostic significance of AIM2 expression and the correlation between AIM2 expression and p‑STAT3 expression in hypopharyngeal squamous cell carcinoma (HSCC), which remain unknown. AIM2 and p‑STAT3 were detected using immunohistochemistry (IHC) in 111 paraffin‑embedded tissue samples from primary HSCC sites and 20 samples from matched adjacent non‑malignant sites. Western blotting was utilized to investigate AIM2, p‑STAT3 and total STAT3 in 5 pairs of fresh tissue samples. Western blotting indicated that AIM2 expression was significantly lower (P<0.05), but that p‑STAT3 levels and the p‑STAT3/STAT3 ratio were higher (P<0.01) in HSCC tissues than in adjacent normal hypopharyngeal tissues. IHC analysis of the 111 HSCC samples revealed low AIM2 and high p‑STAT3 expression in 48 (43.2%) and 58 (52.3%) samples, respectively. High AIM2 expression and low p‑STAT3 expression were detected in 13 (75%) and 18 (90%) adjacent normal hypopharyngeal tissue samples, respectively. In the HSCC samples, low AIM2 expression was closely related to lymph node metastasis and intravascular tumor thrombus (P<0.05). Ka...Continue Reading

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