PMID: 18719738Aug 23, 2008Paper

Low expression of APAF-1XL in acute myeloid leukemia may be associated with the failure of remission induction therapy

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
B D BenitesS T O Saad

Abstract

Apoptotic protease activating factor 1 (APAF-1) has a critical role in the regulation of apoptosis. In the present study, the mRNA expression analysis of different APAF-1 transcripts (APAF-1S, APAF-1LC, APAF-1LN, and APAF-1XL) was analyzed in bone marrow samples from 37 patients with acute myeloid leukemia (newly diagnosed, with no previous treatment). APAF-1XL and APAF-1LN transcripts (with and without an extra WD-40 repeat region, respectively) were detected in all samples, although the major form expressed was APAF-1XL in 65% of the samples (group 1), while 35% of the samples expressed primarily APAF-1LN (group 2). Only 46% of the patients presented complete remission in response to remission induction therapy (represented by less than 5% marrow blasts and hematological recovery), all but 2 cases being from group 1, 21.6% did not attain complete remission (only 1 case from group 1), and 32.4% of the patients died early. Lower expression of APAF-1XL (APAF-1XL/APAF-1LN ratio <1.2) was associated with a poor response to therapy (P = 0.0005, Fisher exact test). Both groups showed similar characteristics regarding white blood cell counts, cytogenetic data or presence of gene rearrangements associated with good prognosis as AML1-E...Continue Reading

References

Jan 26, 1999·European Journal of Haematology·C BincolettoM L Queiroz
Jun 11, 1999·The Journal of Biological Chemistry·A SalehE S Alnemri
Aug 12, 1999·Biochemical and Biophysical Research Communications·C HahnH Stein
Dec 20, 2000·Brain Research·D W Walke, J I Morgan
Jul 4, 2001·Nucleic Acids Research·I I VandenbrouckeL Messiaen
Oct 14, 2003·Cancer Genetics and Cytogenetics·Sílvia CasasSakari Knuutila
Jun 24, 2005·Molecular Cancer Research : MCR·Yutaka FurukawaYusuke Furukawa
Dec 7, 2005·International Journal of Cancer. Journal International Du Cancer·Isrid SturmPeter T Daniel

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Citations

Mar 30, 2010·European Journal of Haematology·Bruno Deltreggia BenitesSara Teresinha Saad

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