Low expression of fibulin-1 correlates with unfavorable prognosis in gastric cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Liang FengWan-Jiang Xue

Abstract

The tumor-suppressing role of fibulin-1 has been described in several types of cancers. However, the expression and role of fibulin-1 in the development and progression of gastric cancer (GC) remain largely unknown. In this study, RT-PCR and immunochemistry were used to detect the fibulin-1 expression in GC samples. We have found that the fibulin-1 protein and mRNA levels were downregulated in GC. When investigating the correlation between fibulin-1 expression and clinicopathological characteristics, we have found that low fibulin-1 protein expression was associated with poor tumor differentiation and advanced N stage. Low fibulin-1 protein expression was also an independent prognostic factor for patient survival. To clarify the reason of fibulin-1 downregulation in GC, the mRNA expression and methylation status of fibulin-1 were examined in GC fresh tissue samples (n = 36). We found that the transcriptional expression of fibulin-1 was negatively associated with fibulin-1 promoter hypermethylation, and fibulin-1 hypermethylation was associated with Helicobacter pylori infection. Finally, the effects of fibulin-1 overexpression on cell proliferation and apoptosis were examined. We have found that fibulin-1 overexpression suppres...Continue Reading

References

Dec 10, 1999·The Journal of Experimental Medicine·A HmadchaE Pintado
Mar 20, 2003·British Journal of Cancer·L M GreeneW M Gallagher
Jun 5, 2003·Nature Reviews. Molecular Cell Biology·Rupert TimplMon-Li Chu
Apr 1, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Mon-Li Chu, Takeshi Tsuda
Jun 18, 2005·Trends in Molecular Medicine·William M GallagherLinda C Whelan
May 1, 2007·Clinical Biochemistry·Amanda C AugustoSonia A Gurgueira
Aug 9, 2007·Journal of Gastroenterology and Hepatology·Wan-Jiang XueHai-Xin Qian
Oct 12, 2007·The Prostate·Agnes WlazlinskiWolfgang A Schulz
Nov 6, 2008·British Journal of Cancer·Y Y ChengF K L Chan
Jan 5, 2012·Nature Reviews. Genetics·Robert Feil, Mario F Fraga
Jan 10, 2013·Annals of Surgical Oncology·Toru KusanoSeigo Kitano
Jun 21, 2013·Expert Review of Molecular Diagnostics·Koji OtaniJun Yu
Aug 3, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bao-Jin WuHua Jiang
Sep 26, 2013·Nature Reviews. Clinical Oncology·Roopma WadhwaJaffer A Ajani
Oct 8, 2013·Lancet·David H Ilson
Oct 11, 2013·Journal of the National Cancer Institute·Koji ObaUNKNOWN GASTRIC group
Oct 16, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlos Gomez-MartinFernando Lopez-Rios
Dec 10, 2013·The Lancet Oncology·Roberta De AngelisUNKNOWN EUROCARE-5 Working Group
Mar 29, 2014·The British Journal of Surgery·A TsuburayaUNKNOWN Stomach Cancer Study Group of the Japan Clinical Oncology Group
May 30, 2014·Nature·Mike May
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 11, 2014·Biochemical and Biophysical Research Communications·Haijun MeiHua Wang
Feb 11, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Waleed O TwalWilliam S Argraves
Jun 16, 2015·Frontiers in Cell and Developmental Biology·Rahul BhomeAlex H Mirnezami

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Citations

Mar 8, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wan-Jiang XueQin-Sheng Mao
Nov 7, 2019·Journal of Cellular and Molecular Medicine·Haoming LuWanjiang Xue
Sep 12, 2019·Frontiers in Oncology·Tania FontanilÁlvaro J Obaya
Nov 11, 2020·Cancers·Jemma DunnMatthias E Futschik

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