Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Xuezhi HeRenhua Guo

Abstract

Recently, long noncoding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancer biology. The aim of this study was to evaluate the expression and biological role of lncRNA CASC2 in non-small cell lung cancer (NSCLC). By bioinformatics analysis, we found that CASC2 was significantly decreased in NSCLC. qRT-PCR was performed to investigate the expression of CASC2 in tumor tissues and corresponding non-tumor NSCLC tissues from 76 patients. The lower expression of CASC2 was remarkably correlated with advanced TNM stage and tumor size. Multivariate analyses found that CASC2 expression served as an independent predictor for overall survival of NSCLC. Moreover, overexpression of CASC2 significantly inhibited NSCLC cell proliferation both in vitro and in vivo. In conclusion, our study demonstrated that CASC2 is involved in the development and progression of NSCLC and shows that CASC2 may be a potential diagnostic and target for new therapies in patients with NSCLC.

References

Apr 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Melanie R GingerJeffrey M Rosen
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Mar 21, 2008·Journal of Cell Science·Mirna Mourtada-MaarabouniGwyn T Williams
Mar 29, 2008·Science·Paulo P AmaralJohn S Mattick
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Jan 25, 2011·Seminars in Cell & Developmental Biology·Michael B Clark, John S Mattick
Jun 6, 2012·RNA Biology·Tony Gutschner, Sven Diederichs
Jul 4, 2012·International Journal of Cancer. Journal International Du Cancer·Freddie BrayJacques Ferlay
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 8, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chou-Han LinChao-Chi Ho
Nov 27, 2014·Neoplasia : an International Journal for Oncology Research·John R PrensnerFelix Y Feng
Dec 3, 2014·Cellular Signalling·Ping WangYi-Xue Xue
Dec 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hai-min ZhangJun-hua Zheng
May 17, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory J Riely, Helena A Yu

❮ Previous
Next ❯

Citations

Nov 5, 2016·Cancer Genetics·Konii TakenakaMichael Janitz
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuanyuan GanXiming Xu
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Heng DengJun Zhang
Mar 8, 2018·Acta Biochimica Et Biophysica Sinica·Zhiqiong WangYifei Wu
Jun 12, 2017·Clinical and Experimental Pharmacology & Physiology·Wenmin XingJing Yan
Sep 3, 2017·Journal of Cellular Biochemistry·Yaqun YuWeijia Liao
Jul 14, 2019·The Journal of Gene Medicine·Noha S RefaiIman Montasser
Jan 22, 2017·Oncotarget·Jian LuoQiang Qu
Nov 16, 2017·Oncotarget·Fan FanJifeng Feng
Oct 6, 2017·Oncotarget·Yuting ZhanSongqing Fan
Mar 16, 2017·Frontiers in Molecular Neuroscience·Yuanliang YanZhicheng Gong
Nov 24, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L KeM-Q Xu
Mar 18, 2019·Cellular and Molecular Life Sciences : CMLS·Shruti MishraSubash C Gupta
Nov 27, 2019·Journal of the Chinese Medical Association : JCMA·Afeez Adekunle IsholaMong-Lien Wang
Aug 8, 2020·Cancer Cell International·Hilda SamimiVahid Haghpanah
Oct 31, 2020·International Journal of Molecular Sciences·Daina SkiriutePaulina Vaitkiene
Aug 3, 2021·The Kaohsiung Journal of Medical Sciences·Zhi-Hui WuMin Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.