Low expression of microRNA-340 confers adverse clinical outcome in patients with acute myeloid leukemia

Journal of Cellular Physiology
Qi WangXue-Jun Shao

Abstract

MicroRNA-340 (miR-340) was considered as a tumor suppressor by affecting cancer cell proliferation, apoptosis, invasion, and migration, and was downregulated in diverse cancers. Moreover, dysregulation of miR-340 was also found to be associated with drug resistance and predicted patients' survival in various cancers. Herein, we investigated miR-340 expression and its clinical significance in acute myeloid leukemia (AML). Real-time quantitative polymerase chain reaction was performed to detect miR-340 expression in bone marrow (BM) from 99 newly diagnosed AML patients except for acute promyelocytic leukemia (APL), 19 AML patients achieved complete remission (CR), and 29 healthy donors. BM miR-340 expression was significantly underexpressed in newly diagnosed AML patients as compared with controls (p = 0.031) and AML patients achieved CR (p = 0.025). No significant differences were observed between miR-340 expression and most of the clinicopathologic features (p > 0.05). However, low miR-340 expression was found to be associated with lower CR rate in both non-APL-AML and cytogenetically normal AML (CN-AML; p = 0.001 and 0.031, respectively), and acted as an independent risk factor for CR by logistic regression analysis (p = 0.001...Continue Reading

References

Jul 13, 2005·Cell·Carlo M Croce, George A Calin
Jan 1, 2009·Cancer Treatment and Research·Milena S NicolosoGeorge A Calin
Nov 4, 2010·Blood·Guido MarcucciClara D Bloomfield
Jul 23, 2013·Biochemical and Biophysical Research Communications·Xin ZhouWei Wang
Jan 9, 2014·International Journal of Molecular Sciences·Haiqing CaiZhigang Wang
Jan 23, 2014·Molecular Cancer Therapeutics·Hiroshi TakeyamaMasaki Mori
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Liang ShiFang Zheng
Mar 31, 2015·Biochemical and Biophysical Research Communications·Xuesong LiMian Guo
Sep 17, 2015·The New England Journal of Medicine·Hartmut DöhnerClara D Bloomfield
Dec 22, 2016·Biochemical and Biophysical Research Communications·Jianyong YuanJunhua Lu
Feb 10, 2017·Breast Cancer Research and Treatment·Mithu RaychaudhuriStefanie Avril
Apr 27, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L SongQ Zhou
Aug 31, 2017·Journal of Translational Medicine·Hui ChengJianmin Yang
Sep 9, 2017·Journal of Cellular Physiology·Ting-Juan ZhangJun Qian
Feb 15, 2018·Journal of Endocrinological Investigation·P ZhaoY Wang
Mar 2, 2018·Anti-cancer Drugs·Haibin YanLiqiu Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.