PMID: 26763596Jan 15, 2016Paper

Low Expression of Mir-137 Predicts Poor Prognosis in Cutaneous Melanoma Patients

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Nan Li

Abstract

BACKGROUND The present study aimed to measure miR-137 expression in patients with cutaneous melanoma (CM) and to estimate the correlation of miR-137 expression and the prognosis of CM patients. MATERIAL AND METHODS The expression level of miR-137 was assayed by quantitative real-time PCR (qRT-PCR) and presented as mean ±SD. Chi-square was used to evaluate the relationship between miR-137 expression and clinical characteristics. We used a Kaplan-Meier survival curve to determine the overall survival rate of CM patients. Moreover, the correlation between miR-137 expression and the prognosis of CM patients was confirmed by Cox regression analysis. RESULTS The relative expression of miR-137 in CM tissue was 1.59±0.43, while that in paired normal tissue was 2.41±0.54, which was significantly higher. Chi-square analysis showed statistical significance between miR-137 expression and clinical characteristics such as TNM stage, ulcer, and occurrence site (P<0.05). However, no association was found between miR-137 expression and age, sex, or family history (P>0.05). According to the survival curve outcome, patients with low miR-137 expression showed relatively higher mortality (P=0.000) and multivariate analysis verified that low express...Continue Reading

Citations

Dec 12, 2017·Journal of Cellular Physiology·Casey L RossRina Anvekar
Nov 7, 2019·Oxidative Medicine and Cellular Longevity·Mari HämäläinenPeeter Karihtala
Sep 28, 2018·Molecular Diagnosis & Therapy·Shanthi SabarimuruganRama Jayaraj
Jun 29, 2016·Molecular Diagnosis & Therapy·Zhenjun DengLi He
Jan 20, 2018·Cell Death and Differentiation·Meiying LuoYongfei Yang
Apr 17, 2020·Cancers·Magali BoyerCatherine Alix-Panabières
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri

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