PMID: 11920465Mar 29, 2002Paper

Low expression of p27(Kip1) is associated with tumor size and poor prognosis in patients with renal cell carcinoma

Cancer
Toshiro MigitaMasazumi Tsuneyoshi

Abstract

Proliferative activity in tumors depends on regulation of the cell cycle. p27(Kip1) (p27) plays a pivotal role as a negative regulator of the cell cycle. A decrease in p27 expression has been reported in many kinds of tumors, but little is known regarding p27 in patients with renal cell carcinoma (RCC). Expression of p27 and the related cyclins (cyclin A, cyclin E, and cyclin D1) was examined immunohistochemically in 67 patients with of clear cell RCC. The Ki-67 labeling index (MIB-1 LI) and clinicopathologic parameters related to a poor prognosis also were analyzed. To determine their prognostic significance, univariate and multivariate survival analyses were performed. In tumors, there was considerable immunoreactivity for cyclin A, cyclin D1, and MIB-1, and the mean values for each were 1.08%, 16.1%, and 1.5%, respectively. Cyclin E expression was rare. The expression of p27 was correlated strongly with the expression of cyclin A (correlation coefficient, 0.432; P < 0.0004) and cyclin D1 (correlation coefficient, 0.476; P < 0.0004). Also, an inverse correlation was present between p27 expression and tumor size (P = 0.0377). In univariate analysis, the unfavorable prognostic factors were high TNM stage (P < 0.0001), large tum...Continue Reading

Citations

Nov 19, 2013·International Urology and Nephrology·M S LimaG E Barros-Silva
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jinhee KimCheryl Lyn Walker
May 11, 2007·Expert Review of Molecular Diagnostics·Zhong Jiang
Jan 2, 2016·Oncology Letters·Miguel Reis DE AlmeidaAbel García-García
May 5, 2010·Pathology·George J Netto, Jonathan I Epstein
Feb 28, 2009·Pathology, Research and Practice·H BarrocaJ Müller-Höcker
Apr 29, 2008·Cancer Treatment Reviews·D FurnissUNKNOWN National Cancer Research Institute Renal Clinical Studies Group
Mar 4, 2008·Urologic Oncology·Mark Nogueira, Hyung L Kim
Oct 13, 2007·Critical Reviews in Oncology/hematology·John S LamRobert A Figlin
Nov 29, 2015·The Urologic Clinics of North America·Laura-Maria KrabbeYair Lotan
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Ylva HedbergGöran Landberg
Jan 23, 2010·Genes, Chromosomes & Cancer·Takahiro KojimaKazuhiko Uchida
Aug 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaobing MiaoSong He
Apr 13, 2010·The Lancet Oncology·Kyle A FurgeBin T Teh
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ji-Gen PingJun-Nian Zheng
May 3, 2019·PloS One·Pauline J den HaanArend F Bos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.