Low extracellular dopamine levels are maintained in the anoxic turtle (Trachemys scripta) striatum

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Sarah L Milton, Peter L Lutz

Abstract

The uncontrolled increase of extracellular dopamine (DA) has been implicated in the pathogenesis of hypoxic/ischemic damage in the mammalian brain. But unlike the harmful release of excitatory neurotransmitters such as glutamate and aspartate, which occurs on brain depolarization, excessive extracellular DA levels occur even with mild hypoxia in the mammalian brain. The purpose of this study was to determine whether hypoxia/anoxia provokes a similar increase in the anoxic tolerant turtle brain. Extracellular DA was measured in the striatum of the turtle using microdialysis followed by high-performance liquid chromatography analysis. Results show that extracellular DA was held to normoxic levels over 4 hours of anoxia. Treatment with the specific DA transport blocker GBR 12909 during anoxia resulted in a significant increase in DA to 236% over basal levels. The ability to maintain low striatal extracellular DA may be an important adaptation for anoxic survival in the turtle brain; a contributing factor is the continued functioning of DA uptake mechanisms during anoxia.

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Citations

Jul 12, 2003·Experimental Gerontology·Peter L LutzSarah L Milton
Nov 3, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·P W Hochachka, P L Lutz
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Anastasia Krivoruchko, Kenneth B Storey
Dec 15, 2007·The Journal of Physiology·Matthew Edward PamenterLeslie Thomas Buck
Oct 19, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Miguel A Perez-Pinzon
Mar 28, 2009·Neuroscience·L B Silverman-GavrilaZ-P Feng
Oct 20, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sarah L Milton, Howard M Prentice
May 7, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Göran E Nilsson, Peter L Lutz
Oct 14, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shijia RenZaiqun Liu
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah L Milton, Peter L Lutz
Dec 9, 1998·The American Journal of Physiology·M Pék-Scott, P L Lutz
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah L MiltonPeter L Lutz
Oct 14, 2003·The Journal of Experimental Biology·Sarah L MiltonPeter L Lutz
Mar 29, 2014·The Journal of Experimental Biology·John LarsonThomas J Park
Aug 4, 2004·Respiratory Physiology & Neurobiology·Peter L Lutz, Göran E Nilsson
Aug 10, 2004·The Journal of Experimental Biology·Peter L Lutz, Sarah L Milton

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