Low factor XIII levels after intravenous thrombolysis predict short-term mortality in ischemic stroke patients

Scientific Reports
Edina G SzékelyZsuzsa Bagoly

Abstract

In this observational study we investigated whether levels of factor XIII (FXIII) and its major polymorphisms affect the outcome of thrombolysis by recombinant tissue plasminogen activator (rtPA) in acute ischemic stroke (AIS) patients. Study cohort included 132 consecutive AIS patients undergoing i.v. thrombolysis within 4.5 h of symptom onset. Blood samples taken on admission, immediately after and 24 h after therapy were analyzed for FXIII activity and antigen levels. FXIII-A p.Val34Leu, p.Tyr204Phe, FXIII-B p.His95Arg and intron K(IVS11 + 144) polymorphisms were genotyped. Neurological deficit was assessed using the National Institutes of Health Stroke Scale. Intracranial hemorrhage was classified according to ECASSII criteria. Long-term functional outcome was defined at 3 months post-event by the modified Rankin scale. FXIII levels showed a gradual decrease immediately after thrombolysis and 24 h later, which was not related to therapy-associated bleeding. In a multiple logistic regression model, a FXIII level in the lowest quartile 24 h post-lysis proved to be an independent predictor of mortality by 14 days post-event (OR:4.95, 95% CI:1.31-18.68, p < 0.05). No association was found between the investigated FXIII polymorp...Continue Reading

References

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Citations

Feb 15, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Woosuk S HurChristian J Kastrup
Nov 17, 2020·Frontiers in Neurology·Joohyun ParkJong Eun Lee
Oct 27, 2021·Pharmacogenomics·Laia Llucià-CarolIsrael Fernández-Cadenas

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

ASPECTS
TOAST
Statistical Package for Social Sciences ( SPSS

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