Low-fat dietary pattern and cardiovascular disease: results from the Women's Health Initiative randomized controlled trial

The American Journal of Clinical Nutrition
Ross L PrenticeBarbara V Howard

Abstract

Background: The influence of a low-fat dietary pattern on the cardiovascular health of postmenopausal women continues to be of public health interest.Objective: This report evaluates low-fat dietary pattern influences on cardiovascular disease (CVD) incidence and mortality during the intervention and postintervention phases of the Women's Health Initiative Dietary Modification Trial.Design: Participants comprised 48,835 postmenopausal women aged 50-79 y; 40% were randomly assigned to a low-fat dietary pattern intervention (target of 20% of energy from fat), and 60% were randomly assigned to a usual diet comparison group. The 8.3-y intervention period ended in March 2005, after which >80% of surviving participants consented to additional active follow-up through September 2010; all participants were followed for mortality through 2013. Breast and colorectal cancer were the primary trial outcomes, and coronary heart disease (CHD) and overall CVD were additional designated outcomes.Results: Incidence rates for CHD and total CVD did not differ between the intervention and comparison groups in either the intervention or postintervention period. However, CHD HRs comparing these groups varied strongly with baseline CVD and hypertensio...Continue Reading

Associated Clinical Trials

Citations

Oct 3, 2018·Nutrients·Hayley E BillingsleyCarl J Lavie
Apr 19, 2019·European Journal of Preventive Cardiology·Guilherme Neif Vieira MusseMarcos Ferreira Minicucci
Feb 8, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rowan T ChlebowskiUNKNOWN Women’s Health Initiative
May 20, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jun 4, 2020·The American Journal of Clinical Nutrition·Ronald M Krauss, Penny M Kris-Etherton
Jul 4, 2020·The American Journal of Clinical Nutrition·Sabina SieriVittorio Krogh
Aug 23, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jan 1, 2018·Statistical Theory and Related Fields·Ross L Prentice, Ying Huang
Mar 3, 2020·Journal of Nutritional Science and Vitaminology·Aya Kito, Eri Imai
Apr 27, 2018·Current Atherosclerosis Reports·Peter M Clifton, Jennifer B Keogh
Nov 18, 2018·Science·David S LudwigMarian L Neuhouser
Oct 3, 2020·Nutrients·Sara Castro-BarqueroRosa Casas
Mar 13, 2018·The American Journal of Clinical Nutrition·Ross L PrenticeBarbara V Howard
Mar 8, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Ronald L Koretz
Aug 23, 2019·Journal of the American Heart Association·Alvaro AlonsoBailey M DeBarmore
May 1, 2020·BMC Complementary Medicine and Therapies·Martiné WlosinskaSandra Lindstedt
Dec 22, 2020·Lancet Neurology·Coralie EnglishGraeme J Hankey
Jan 8, 2021·Nutrition Research Reviews·Jacques Delarue
Feb 9, 2021·The Cochrane Database of Systematic Reviews·Thomas SemlitschAndrea Siebenhofer
Mar 20, 2021·Critical Reviews in Food Science and Nutrition·Noushin MohammadifardFahimeh Haghighatdoost
Apr 22, 2021·The Journal of Nutrition·Ross L PrenticeJohanna W Lampe
Apr 21, 2021·The American Journal of Clinical Nutrition·Ross L PrenticeRowan T Chlebowski
May 13, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Herculina S KrugerAletta E Schutte
Aug 31, 2021·Nutrition·Nara Aline CostaMarcos Ferreira Minicucci
Aug 15, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Nese YukselMichel Fortier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.