Low fecal elastase-1 in type I diabetes mellitus

Zeitschrift für Gastroenterologie
A IcksW Rathmann

Abstract

Previous studies suggested impaired pancreatic exocrine function in type I diabetes patients, but have been limited by small or highly selected samples. Fecal elastase-1 has facilitated evaluation of pancreatic dysfunction in population-based studies. 112 type I diabetic patients (age +/- SD: 37 +/- 11 years; 47 % males; diabetes duration: 12.5 +/- 10.5 years) were consecutively selected from main regional diabetes centers in Essen, West-Germany. 116 non-diabetic control subjects, similar with respect to age and sex, were recruited from the same geographical region. Elastase-1 measurement was performed centrally by ELISA (ScheboTech, Germany). Elastase-1 concentrations in type I diabetic patients were significantly lower than in control subjects (median; inter-quartile range: diabetic patients: 227, 98-386 microgram/g stool; non-diabetic subjects: 544, 377-702 microgram/g stool) (p < 0.01). Elastase-1 < 100 microgram/g stool (E1 < 100) was found in 25.9 % of diabetic and 5.2 % of non-diabetic subjects, yielding an age-sex-adjusted prevalence Odds ratio (POR; 95 % CI) for diabetes and E1 < 100 of 6.9 (2.8-19.6). After adjusting for potential confounders (history of gastrointestinal diseases, smoking, alcohol consumption) the str...Continue Reading

Citations

Jun 12, 2004·Current Gastroenterology Reports·Paul G Lankisch
Jul 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Miroslav VujasinovicSasa Rudolf
Oct 4, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Philip D HardtUNKNOWN S2453112/S2453113 Study Group
Dec 7, 2013·World Journal of Gastroenterology : WJG·Raffaele PezzilliUNKNOWN Exocrine Pancreatic Insufficiency collaborative (EPIc) Group
Feb 12, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Luigi BeniniLuca Frulloni
Dec 20, 2012·Wiener klinische Wochenschrift·Raimund WeitgasserHeinz Hammer
Feb 5, 2013·European Journal of Internal Medicine·Nils Ewald, Reinhard G Bretzel
Aug 19, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Alan EricksonEdward R Ashwood
Nov 10, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·C ShivaprasadK M Prasanna Kumar
May 1, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·T KlupaM T Malecki
Nov 29, 2011·Diabetes/metabolism Research and Reviews·N EwaldP D Hardt
Apr 18, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Wolfgang RathmannNicholas J Wareham
Apr 8, 2016·Wiener klinische Wochenschrift·Raimund WeitgasserHeinz F Hammer
Apr 22, 2015·International Journal of Endocrinology·Matteo PiciucchiGianfranco Delle Fave
Nov 9, 2007·Diabetes Care·Mette VesterhusPål R Njølstad
Feb 15, 2008·Diabetes Care·Philip D HardtReinhard G Bretzel
Dec 23, 2003·The American Journal of Gastroenterology·Amadeu C R NunesDiniz Freitas
Jun 2, 2011·Nature Reviews. Gastroenterology & Hepatology·John S LeedsDavid S Sanders
Dec 22, 2005·Nature Genetics·Helge RaederPål Rasmus Njølstad
May 12, 2019·Reviews in Endocrine & Metabolic Disorders·Laure Alexandre-HeymannEtienne Larger
Jun 22, 2012·MMW Fortschritte der Medizin·Philip D HardtOliver Schnell
Dec 11, 2014·World Journal of Gastroenterology : WJG·Stephanie L M DasMaxim S Petrov
Feb 12, 2019·Acta Diabetologica·Laure Alexandre-HeymannEtienne Larger
Apr 14, 2019·Wiener klinische Wochenschrift·Susanne KaserAnton Luger
Apr 3, 2020·Current Diabetes Reports·Bernhard RadlingerSusanne Kaser
Nov 3, 2017·World Journal of Gastroenterology : WJG·Vikesh K SinghPedro M Quintana Diez
Nov 15, 2019·Frontline Gastroenterology·Kwan Wai Lam, John Leeds
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Timothy P FosterDesmond A Schatz
Oct 20, 2010·The Medical Journal of Australia·James ToouliUNKNOWN Australasian Pancreatic Club
Jun 19, 2021·BMJ Open Gastroenterology·Mary E PhillipsRajesh Kumar
Jul 2, 2021·Journal of Veterinary Internal Medicine·Kristen HamiltonChen Gilor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.