Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice.

Cancer Research
Hironobu YasuiMurali C Krishna

Abstract

Tumors exhibit fluctuations in blood flow that influence oxygen concentrations and therapeutic resistance. To assist therapeutic planning and improve prognosis, noninvasive dynamic imaging of spatial and temporal variations in oxygen partial pressure (pO(2)) would be useful. Here, we illustrate the use of pulsed electron paramagnetic resonance imaging (EPRI) as a novel imaging method to directly monitor fluctuations in oxygen concentrations in mouse models. A common resonator platform for both EPRI and magnetic resonance imaging (MRI) provided pO(2) maps with anatomic guidance and microvessel density. Oxygen images acquired every 3 minutes for a total of 30 minutes in two different tumor types revealed that fluctuation patterns in pO(2) are dependent on tumor size and tumor type. The magnitude of fluctuations in pO(2) in SCCVII tumors ranged between 2- to 18-fold, whereas the fluctuations in HT29 xenografts were of lower magnitude. Alternating breathing cycles with air or carbogen (95% O(2) plus 5% CO(2)) distinguished higher and lower sensitivity regions, which responded to carbogen, corresponding to cycling hypoxia and chronic hypoxia, respectively. Immunohistochemical analysis suggests that the fluctuation in pO(2) correlate...Continue Reading

References

Jan 1, 1987·Cancer Metastasis Reviews·R K Jain
May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·R A GatenbyG J Broder
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C S LaiS Lukiewicz
Jul 9, 1998·Journal of Magnetic Resonance·J H Ardenkjaer-LarsenK Golman
Feb 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D M BrizelM W Dewhirst
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·J. Martin Brown
May 15, 2002·The Cancer Journal·Steven A LeibelC Clifton Ling
Jul 31, 2002·Zeitschrift für medizinische Physik·Ludwig Bogner
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sankaran SubramanianMurali C Krishna
Mar 26, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martyna ElasHoward J Halpern
Nov 7, 2003·Current Molecular Medicine·R A CairnsR P Hill
Sep 3, 2004·Cancer Research·Kevin L Bennewith, Ralph E Durand
Sep 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ken-Ichiro MatsumotoMurali C Krishna
Sep 24, 2005·Journal of Biomedical Optics·Brian S SorgMark W Dewhirst
Jan 6, 2006·Radiation Research·Kjetil G BrurbergEinar K Rofstad
Apr 6, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ken-ichiro MatsumotoMurali C Krishna
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martyna ElasHoward J Halpern
Mar 29, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nallathamby DevasahayamMurali C Krishna
Mar 31, 2007·Nature Reviews. Drug Discovery·Judah Folkman
Jun 15, 2007·Microvascular Research·Dai Fukumura, Rakesh K Jain
Mar 4, 2008·International Journal of Radiation Oncology, Biology, Physics·Zhixiong LinC Clifton Ling
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qingyu ZhouJames M Gallo
Apr 24, 2008·The Journal of Clinical Investigation·Shingo MatsumotoMurali C Krishna
May 14, 2008·International Journal of Radiation Oncology, Biology, Physics·Martyna ElasHoward J Halpern
Jan 23, 2009·Journal of Magnetic Resonance·Fuminori HyodoMurali C Krishna
Aug 13, 2009·International Journal of Biomedical Imaging·Christopher D DharmarajMurali C Krishna
Sep 3, 2009·International Journal of Oncology·Fuminori HyodoJeeva P Munasinghe
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shingo MatsumotoMurali C Krishna
Nov 26, 2009·Medical Physics·Kelin WangC Clifton Ling

❮ Previous
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Citations

Dec 17, 2010·Cancer Research·Shingo MatsumotoMurali C Krishna
Nov 19, 2013·PLoS Computational Biology·Harald KempfMichael Meyer-Hermann
Dec 23, 2011·International Journal of Cell Biology·Katrin SchlieJulian J Lum
Mar 19, 2014·Advanced Drug Delivery Reviews·Claudio R ThomaWilhelm Krek
Dec 18, 2013·Antioxidants & Redox Signaling·Chen-Ting LeeMark W Dewhirst
Jun 17, 2014·Seminars in Radiation Oncology·Masayuki MatsuoKevin Camphausen
Mar 29, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C Bayer, P Vaupel
Sep 3, 2013·Acta Oncologica·Thomas NielsenMorten Busk
Oct 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Keita SaitoMurali C Krishna
Jun 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shingo MatsumotoMurali C Krishna
Aug 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hyungseok JangAlan B McMillan
Jul 15, 2015·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·Gage RedlerHoward J Halpern
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Boris EpelHoward J Halpern
Feb 13, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gage RedlerHoward J Halpern
Nov 21, 2015·Molecular Cancer·C SanhuezaA F G Quest
May 7, 2011·Radiation Research·James B Mitchell
Feb 16, 2012·Radiation Research·Murali C KrishnaJames B Mitchell
Jan 25, 2012·International Journal of Radiation Oncology, Biology, Physics·Christine EllingsenEinar K Rofstad
Feb 24, 2015·Seminars in Nuclear Medicine·Cameron J Koch, Sydney M Evans
Jun 28, 2016·Biochimica Et Biophysica Acta·Carine MichielsOlivier Feron
Aug 9, 2016·Journal of Magnetic Resonance·Anthony G ChristodoulouBoris Epel
Aug 2, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shingo Matsumoto
Aug 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Alzbeta HulikovaPawel Swietach
Oct 25, 2016·Nature Reviews. Cancer·Florian Röhrig, Almut Schulze
Nov 12, 2016·Bioorganic & Medicinal Chemistry Letters·Ilirian DhimitrukaJay L Zweier
Aug 15, 2015·PloS One·Harald KempfMichael Meyer-Hermann
Sep 21, 2016·Bioorganic & Medicinal Chemistry Letters·Ryohsuke KuriharaKazuhito Tanabe
May 16, 2017·Chembiochem : a European Journal of Chemical Biology·Kazuki YoshiharaKazuhito Tanabe
Jun 22, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Takuya ToyonagaTamaki Nagara
Nov 14, 2017·Antioxidants & Redox Signaling·Shun KishimotoMurali C Krishna
Jul 26, 2017·Antioxidants & Redox Signaling·Yoichi TakakusagiMurali C Krishna
Sep 1, 2018·NMR in Biomedicine·Shun KishimotoRobert J Gillies
Jun 21, 2012·British Journal of Cancer·I M PiresE M Hammond
Oct 21, 2015·British Journal of Cancer·Miguel R GonçalvesSimon Walker-Samuel
Oct 9, 2013·The Journal of Biological Chemistry·An-Hoa GiangRoman Eliseev

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