PMID: 8604926Dec 1, 1995Paper

Low-flow cardiopulmonary bypass: importance of blood pressure in maintaining cerebral blood flow

The Annals of Thoracic Surgery
R E MichlerA E Schwartz

Abstract

During cardiopulmonary bypass (CPB), global hypoperfusion of the brain has been shown to result in ischemic insult and subsequent neurologic injury. We measured cerebral blood flow during independent manipulations of arterial blood pressure and pump flow rate to determine which of these hemodynamic parameters regulates cerebral perfusion during CPB. Seven adolescent baboons were placed on CPB and cooled to 28 degrees C. Pump flow rate and arterial blood pressure were altered in varied sequence to each of four conditions: (1) full flow (2.23 +/- 0.06 L.min-1.m-2, mean +/- standard deviation) at high pressure (61 +/- 2 mm Hg), (2) full flow (2.23 +/- 0.06 L.min-1.m-2) at low pressure (24 +/- 3 mm Hg), (3) low flow (0.75 L.min-1.m-2) at high pressure (62 +/- 2 mm Hg), and (4) low flow (0.75 L.min-1.m-2) at low pressure (23 +/- 3 mm Hg). During each of these hemodynamic conditions cerebral blood flow was measured by washout of intracarotid xenon 133. Cerebral blood flow was greater at high blood pressure than at low pressure during CPB both at low flow (34 +/- 8.3 versus 14.1 +/- 3.7 mL.min-1.100 g-1) and full flow (27.6 +/- 9.9 versus 16.8 +/- 3.7 mL.min-1.100 g-1) (p < 0.01). At comparable mean arterial blood pressure, alteration...Continue Reading

Citations

Feb 24, 2009·Journal of Neurotrauma·G Burkhard MackensenDavid S Warner
Aug 5, 2014·The Annals of Thoracic Surgery·Yavuzer Koza
Jul 10, 2013·Anesthesiology·Kenneth Brady, Charles W Hogue
Apr 24, 2014·Anesthesiology·Arthur E Schwartz
Jul 4, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Syuji InamoriMotomu Minamiyama
Aug 14, 2002·Acta Neurologica Scandinavica·S L M BakkerP J Koudstaal

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