Low frequencies, but not high frequencies of bi-polar spinal cord stimulation reduce cutaneous and muscle hyperalgesia induced by nerve injury

Pain
Yumi MaedaK A Sluka

Abstract

Spinal cord stimulation (SCS) is an established treatment for neuropathic pain. However, SCS is not effective for all the patients and the mechanisms underlying the reduction in pain by SCS are not clearly understood. To elucidate the mechanisms of pain relief by SCS, we utilized the spared nerve injury model. Sprague-Dawley rats were anesthetized, the tibial and common peroneal nerves were tightly ligated, and an epidural SCS lead implanted in the upper lumbar spinal cord. SCS was delivered daily at one of 4 different frequencies (4Hz, 60Hz, 100Hz, and 250Hz) at approximately 85% of motor threshold 2 weeks after nerve injury for 4 days. Mechanical withdrawal threshold of the paw and compression withdrawal threshold of the hamstring muscles were measured before and after SCS on each day. All rats showed a decrease in withdrawal threshold of the paw and the muscle 2 weeks after nerve injury. Treatment with either 4Hz or 60Hz SCS significantly reversed the decreased withdrawal threshold of the paw and muscle. The effect was cumulative with a greater reversal by the fourth treatment when compared to the first treatment. Treatment with 100Hz, 250Hz or sham SCS had no significant effect on the decreased withdrawal threshold of the p...Continue Reading

References

May 1, 1993·Journal of Neurophysiology·J W LeemJ M Chung
Nov 1, 1996·Pain·F Cervero, J M Laird
Sep 18, 2001·European Journal of Pain : EJP·J P Van BuytenL Vanduffel
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Barbara Rakel, Rita Frantz
Nov 16, 2004·European Journal of Pharmacology·Marcos A ResendeJanetti N Francischi
Jan 5, 2005·The Journal of Pain : Official Journal of the American Pain Society·David A SkybaKathleen A Sluka
Mar 15, 2006·Neuroscience Letters·Dianyou LiBengt Linderoth
May 2, 2006·Journal of Pain and Symptom Management·Björn A Meyerson, Bengt Linderoth
Sep 12, 2006·Journal of Neurosurgery. Spine·Krishna KumarShivani Gupta
Feb 13, 2007·The Journal of Pain : Official Journal of the American Pain Society·Takeshi YokoyamaKathleen A Sluka

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Citations

Mar 9, 2012·Current Pain and Headache Reports·Yun Guan
Oct 14, 2011·Neuromodulation : Journal of the International Neuromodulation Society·Kristian R HarrebyJohannes J Struijk
Mar 1, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Chao QinRobert D Foreman
Feb 28, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Louis P Vera-PortocarreroLisa M Johanek
Jul 12, 2012·Pain Practice : the Official Journal of World Institute of Pain·Helwin SmitsElbert A J Joosten
Jul 2, 2010·European Journal of Pain : EJP·Michiel TruinElbert A J Joosten
Apr 24, 2013·European Journal of Pain : EJP·W A PluijmsE A Joosten
Feb 17, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Dana M TilleyDavid L Cedeño
Jun 2, 2009·The Journal of Hand Surgery·Catherine Curtin, Ian Carroll
Oct 14, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Fei YangYun Guan
Apr 11, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Shinsuke InoueKathleen A Sluka
Jan 19, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Huixian LiWeiping Cheng
Nov 20, 2018·Molecular Pain·Kimberly E StephensYun Guan
Dec 18, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Zhiyong ChenYun Guan
Feb 21, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Víctor M López-ÁlvarezXavier Navarro
Jun 1, 2020·Pain Practice : the Official Journal of World Institute of Pain·Liting SunChi Wai Cheung

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