Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement.

Scientific Reports
Ai-Ho LiaoHao-Li Liu

Abstract

Ultrasound (US) has been found to rejuvenate and invigorate the hair follicles, increase the size of hair shafts, and promote new hair growth. Our present study found that dual-frequency US-mediated microbubble (MB) cavitation significantly enhanced minoxidil (Mx) delivery in both in vitro and in vivo models, while increasing the hair growth efficacy compared to single-frequency US sonication. The in vitro experiments showed that cavitation activity was enhanced more significantly during dual-frequency sonication than single-frequency sonication in higher concentration of MBs. The pigskin penetration depth in the group in which dual-frequency US was combined with MBs was 1.54 and 2.86 times greater than for single-frequency US combined with MBs and in the control group, respectively; the corresponding increases in the release rate of Mx at 18 hours in in vitro Franz-diffusion-cell experiments were 24.9% and 43.7%. During 21 days of treatment in C57BL/6J mice experiments, the growth rate at day 11 in the group in which dual-frequency US was combined with MBs increased by 2.07 times compared to single-frequency US combined with MBs. These results indicate that dual-frequency US-mediated MB cavitation can significantly increase bo...Continue Reading

References

Feb 1, 1989·Physical Therapy·H A BensonR Harland
Aug 11, 1995·Science·S MitragotriR Langer
Jul 1, 1997·Ultrasonics Sonochemistry·G LernettiG K Johri
May 19, 2001·BMJ : British Medical Journal·M J BlomleyD O Cosgrove
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Vera H Price
Sep 29, 2004·Drug Discovery Today·Samir Mitragotri
Nov 3, 2005·Physics in Medicine and Biology·E Sassaroli, K Hynynen
Mar 10, 2007·Ultrasonics Sonochemistry·Amir H BaratiZahir M Hassan
Oct 28, 2008·Ultrasonics Sonochemistry·Hao-Li Liu, Chao-Ming Hsieh
Nov 18, 2008·International Journal of Pharmaceutics·Afendi DahlanSudaxshina Murdan
Oct 23, 2009·IEEE Transactions on Bio-medical Engineering·James J ChoiElisa E Konofagou
Jan 12, 2010·International Journal of Pharmaceutics·Yi-Hung TsaiPao-Chu Wu
Aug 17, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Roel Deckers, Chrit T W Moonen
Sep 4, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carl M SchoellhammerDaniel Blankschtein
Aug 1, 2013·Ultrasonics·Donghee ParkSeunghun Lee
Jan 28, 2014·Advanced Drug Delivery Reviews·Aharon AzaguryJoseph Kost
Oct 8, 2014·Therapeutic Delivery·Matthias A OberliDaniel Blankschtein
Feb 11, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carl M SchoellhammerDaniel Blankschtein
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ai-Ho LiaoMeng-Yu Yang
Jul 16, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunali BhatnagarRobert C Carlisle
May 11, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jun Yeong ParkKwang Ho Kim
Dec 13, 2018·International Journal of Nanomedicine·Brenden Cheong-Qi Seah, Boon Mian Teo
Mar 19, 2019·Chemical Engineering Journal·Giancarlo CanaveseValentina Cauda

❮ Previous
Next ❯

Citations

Sep 6, 2020·International Journal of Molecular Sciences·Krystyna Mojsiewicz-PieńkowskaFrans Meijer
Aug 31, 2021·ACS Biomaterials Science & Engineering·Kahkashan BansalHimanshu Shekhar

❮ Previous
Next ❯

Methods Mentioned

BETA
light-microscopy

Software Mentioned

HistoQuest
TissueFAXS
TissueQuest
Mx
Chroma
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.